Synaptic Transmission
Mostrando 1-12 de 637 artigos, teses e dissertações.
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1. Comparing the effects of vitamin E tocotrienol-rich fraction supplementation and α-tocopherol supplementation on gene expression in healthy older adults
OBJECTIVES This study aims to compare the differential gene expression resulting from tocotrienol-rich fraction and α-tocopherol supplementation in healthy older adults. METHODS A total of 71 eligible subjects aged 50 to 55 years from Gombak and Kuala Lumpur, Malaysia, were divided into three groups and supplemented with placebo (n=23), α-tocopherol (n
Clinics. Publicado em: 11/03/2019
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2. Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid
ABSTRACT Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders.
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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3. Exposure to 50 Hz electromagnetic field changes the efficiency of the scorpion alpha toxin
AbstractBackground Extremely low-frequency (50 Hz) electromagnetic field (ELF-EMF) is produced by electric power transmission lines and electronic devices of everyday use. Some phenomena are proposed as “first effects” of ELF-EMF: the discrete changes in the membrane potential and the increase of the calcium channel activity as well as the intracellular
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/10/2015
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4. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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5. Expressão gênica e protéica do canal de cálcio do tipo L e seu envolvimento com o mecanismo de secreção de insulina em ilhotas de langerhans de ratos submetidos à restrição protéica e suplementados com leucina / Gene and protein expression of L type calcium channel and your involvement in the mechanism of insulin secretion in islets of Langerhans of rats submitted to protein restriction and supplementation with leucine
Voltage-dependent calcium channels (CaV) are plasma membrane proteins that lead calcium, and are activated by depolarization of the same by promoting the influx of this ion, which serves as an intracellular second messenger, turning electrical signals into chemical. This process controls several intracellular events such as exocytosis, endocytosis, muscle co
Publicado em: 2010
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6. Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update
Growing consistent evidence indicates that hypofunction of N-methyl-D-aspartate (NMDA) transmission plays a pivotal role in the neuropathophysiology of schizophrenia. Hence, drugs which modulate NMDA neurotransmission are promising approaches to the treatment of schizophrenia. The aim of this article is to review clinical trials with novel compounds acting o
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-11
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7. The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model
The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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8. Influence of Glatiramer acetate on the synaptic stability and glial reaction during the EAE and after motor root avulsion / Influencia do acetato de glatiramer (AG) sobre a estabilidade sinaptica e reação glial durante o curso da EAE e apos avulsão de raizes motoras
Multiple sclerosis (MS) is an inflammatory and demyelinating disease, which etiology is unknown. Although it is the result of a major autoimmune response. The Glatiramer acetate (GA) is a drug used to treat MS and is composed by four peptides homologous to the myelin basic protein (MBP), that is able to reduce the exacerbation and injuries to the CNS. Nevert
Publicado em: 2009
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9. Avaliação neuroquímica do sistema colinérgico de camundongos com o gene do transportador vesicular de acetilcolina (VAChT) modificado geneticamente
The vesicular acetylcholine transporter (VACht) is responsible for acetylcholine (Ach) storage in synaptic vesicles, an important step for cholinergic transmission. Our goal was to study the role of VAChT in cholinergic tonus maintenance through the generation of mice presenting alterations in VAChT gene by homologous recombination.. One of used strategies w
Publicado em: 2008
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10. Estudo das atividades neurotoxica e miotoxica de uma fosfolipase A2 basica isolada do veneno total Bothrops marajoensis / Study of neurotoxic and myotoxic activities of a phospholipase A2 isolated from the Bothrops marajoensis venom
In the present work, the neuromuscular effects of the toxin Bmaj-9 isolated from the venom of Bothrops marajoensis in the laboratory of chemistry of proteins at Unicamp were studied. This toxin was assayed in biventer cervicis preparations of little chicken, phrenic diaphragm nerve of mice and in gastrocnemius muscles of mice. In birds preparation, Bmaj-9 ca
Publicado em: 2008
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11. Expressão e purificação de proteinas relacionadas a epilepsia / Expression and purification of epilepsy related proteins
Non-ion channel genes, as LGI1 and EFHC1, have been shown to indirectly affect ion channel currents in genetically determined epilepsy syndromes. LGI1 (Leucine-rich, glioma inactivated gene 1) is linked to a rare form of partial epilepsy (autosomal dominant partial epilepsy with auditory features, ADPEAF). Recently, LGI1 protein was associated with ADAM22 in
Publicado em: 2007
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12. Influencia dos anestesicos locais no bloqueio neuromuscular produzido por diferentes bloqueadores neuromusculares : estudo experimental / The influence of local anesthetics on neuromuscular blockade produced by differents neuromusculars blockades : experimental study
Local anesthetics commonly used in clinical practice can interact with neuromuscular blockers and potentiate their effects. Many authors studied this interaction, but the mechanism involved in the potentiation of neuromuscular blockers and the action of local anesthetics in the pre and postjunctional sites were not completely elucidated- In this study, in sp
Publicado em: 2006