Synaptic Vesicles
Mostrando 1-12 de 294 artigos, teses e dissertações.
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1. Estudo dos grânulos de lipofucsina e das sinapses do córtex temporal durante o envelhecimento / Study of lipofuscin granules and synapses in the temporal cortex during aging.
Alterações morfológicas e funcionais ocorrem durante o envelhecimento, período da vida com maior incidência de doenças neurodegenerativas. No presente trabalho acompanhou-se a evolução dos grânulos de lipofucsina durante o envelhecimento para investigar alterações sinápticas, assim como proteínas associadas com doenças neurodegenerativas (alfa-
Publicado em: 2011
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2. Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held
The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These changes reduce short-term synaptic depression during tetanic stimulation and thereby prevent action potential failures during a stimulus
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
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3. Avaliação neuroquímica do sistema colinérgico de camundongos com o gene do transportador vesicular de acetilcolina (VAChT) modificado geneticamente
The vesicular acetylcholine transporter (VACht) is responsible for acetylcholine (Ach) storage in synaptic vesicles, an important step for cholinergic transmission. Our goal was to study the role of VAChT in cholinergic tonus maintenance through the generation of mice presenting alterations in VAChT gene by homologous recombination.. One of used strategies w
Publicado em: 2008
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4. Sinais de tráfego envolvidos no envolvidos no endereçamento do transportador vesicular de acetilcolina (VAChT)
The vesicular acetylcholine transporter (VAChT) is the protein responsible for packaging cytoplasmic acetylcholine (ACh) into the synaptic vesicle of cholinergic neurons. The cytosolic C-terminal region of VAChT is important in intracellular trafficking events and targeting to secretory organelles. In this study, we evaluate the existence of trafficking sign
Publicado em: 2006
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5. Funções motoras em camundongos deficientes do transportador vesicular de acetilcolina (VAChT)
Acetylcholine (ACh)mediated neurotransmission has a crucial role in the control of movement. Release of ACh depends on its storage in synaptic vesicles, a step controlled by the activity of the VAChT. We developed a genetically altered strain of mice with reduced expression of this transporter. Heterozygous (VAChT KDHET) and homozygous (VAChT KDHOM) knockdow
Publicado em: 2006
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6. Immunohistochemical investigation of neuronal injury in cerebral cortex of cobra-envenomed rats
The immunohistochemical expression of neuron-specific enolase, NSE (a cytoplasmic glycolytic enzyme of the neurons), synaptophysin, SYN (a major membrane glycoprotein of synaptic vesicles), and Bcl-2 (anti-apoptotic protein) were determined in cerebral cortex of rats envenomed with neurotoxic venom from Egyptian cobra. Male rats were intramuscularly (IM) inj
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2004
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7. Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice
Synaptojanin 1 is a polyphosphoinositide phosphatase implicated in synaptic vesicle recycling. We used FM1-43 imaging and electron microscopy in cultured cortical neurons from control and synaptojanin 1 knockout mice to study how the absence of this protein affects specific steps of the synaptic vesicle cycle. Exo/endocytosis after a moderate stimulus was un
National Academy of Sciences.
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8. Normal Biogenesis and Cycling of Empty Synaptic Vesicles in Dopamine Neurons of Vesicular Monoamine Transporter 2 Knockout Mice
The neuronal isoform of vesicular monoamine transporter, VMAT2, is responsible for packaging dopamine and other monoamines into synaptic vesicles and thereby plays an essential role in dopamine neurotransmission. Dopamine neurons in mice lacking VMAT2 are unable to store or release dopamine from their synaptic vesicles. To determine how VMAT2-mediated fillin
The American Society for Cell Biology.
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9. Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton
Actin is an abundant component of nerve terminals that has been implicated at multiple steps of the synaptic vesicle cycle, including reversible anchoring, exocytosis, and recycling of synaptic vesicles. In the present study we used the lamprey reticulospinal synapse to examine the role of actin at the site of synaptic vesicle recycling, the endocytic zone.
National Academy of Sciences.
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10. ATP-dependent directional movement of rat synaptic vesicles injected into the presynaptic terminal of squid giant synapse.
The question as to whether synaptic vesicles prepared from vertebrate brain can be transported to the active zones of the squid giant synapse was studied by using a combined optical and electrophysiological approach. In order to visualize the behavior of the vertebrate synaptic vesicles in situ, synaptic vesicles isolated from rat brain were labeled with a f
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11. Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
Neurotransmitter release requires the specific docking of synaptic vesicles to the presynaptic plasma membrane followed by a calcium-triggered fusion event. Herein we report a previously unsuspected interaction of the synaptic vesicle protein and likely calcium sensor synaptotagmin with the plasma membrane t-SNARE SNAP-25. This interaction appears to resolve
The National Academy of Sciences of the USA.
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12. Synaptic endings and their postsynaptic targets in neostriatum: synaptic specializations revealed from analysis of serial sections.
Neostriatal tissue from rat brain was examined in ribbons of serial sections, using tissue from subjects in which the synaptic marker 5-hydroxydopamine had been injected into the lateral ventricle. A total of 440 synaptic terminals, identified by the presence of a population of vesicles, was studied, including those labeled by 5-hydroxydopamine and all those