Synovitis Animal
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Efeitos diferenciais do sulfeto de hidrogênio exógeno e endógeno na sinovite experimental induzida por carragenina em ratos Wistar. / Differential effects of hydrogen sulphide exogenous and endogenous in experimental synovitis induced by carrageenan in Wistar rats.
Este estudo se propôs a avaliar o efeito do gás sulfídrico (H2S), produzido endogenamente em mamíferos, na sinovite induzida pela injeção intra-articular de carragenina (CGN) no joelho de ratos Wistar (250 g). Ratos foram tratados (-60 min) com indometacina, o inibidor da cistationina g-liase DL-propargilglicine (PGly) ou doador de
Publicado em: 2010
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2. Efeito da administração do antagonista do receptor da bombesina/peptídeo liberador da gastrina RC-3095 na artrite induzida por CFA em ratos wistar
O peptídeo liberador da gastrina (GRP), homólogo mamífero da bombesina (BN), é um neuropeptídeo com múltiplas ações biológicas, incluindo um importante papel na regulação da resposta imunológica e inflamatória. Está presente em altas concentrações no líquido sinovial de pacientes com artrite reumatóide (AR), paralelamente com os níveis de
Publicado em: 2008
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3. Comparação da resposta inflamatória articular decorrente da distensão líquida ou gasosa em eqüinos submetidos a exame artroscópico / Comparison of the inflammatory response due to liquid or gas joint distension for arthroscopic examination in horses
A ocorrência de lesões intra-articulares é uma das principais causas de incapacidade em atletas, sejam eles humanos ou da espécie eqüina. Um dos grandes avanços observados na medicina esportiva foi o advento das cirurgias intra-articulares minimamente invasivas, realizadas com auxílio de um artroscópio. A artroscopia é técnica diagnóstica ou cirú
Publicado em: 2006
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4. Morphological and biochemical analysis of the synovia of rabbits immunized with type V collagen / "Análise morfológica e bioquímica da sinóvia de coelhos imunizados com colágeno do tipo V"
We described an original model of experimental synovitis in rabbits immunized with collagen V with scant cellular infiltration, intense matrix remodeling and vasculitis. Morphological and biochemical analysis were realized in New Zealand female rabbits (N=20) immunization with type V collagen, compared with control rabbits. It was observed increase of collag
Publicado em: 2005
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5. Influence of x-ray treatment on antigen-induced experimental arthritis.
Six groups of 3 rabbits each were immunised with ovalbumin and received one intra-articular injection of antigen. The animals of 3 groups received local x-ray irradiation of 600 rads for 8 minutes to the right knee joint 12 days after the intra-articular challenge. Animals of the other 3 groups were not irradiated. The antigen-induced arthritis was investiga
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6. New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis.
A dose-dependent chronic synovitis was induced in rabbit knees after the intra-articular injection of both Mycoplasma arthritidis and Mycoplasma pulmonis. The inflammation progressed from an initial acute phase at 1 week characterized by edema, infiltration of the synovium with monocytes and heterophils, and desquamation of lining cells, to a more chronic ph
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7. Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis
Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production. In animal models of arthritis, treatment with recombinant human IL-11 (rhIL-11) reduces both the level of synovitis and the histologic lesion scores in the
BioMed Central.
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8. Induction of lyme arthritis in LSH hamsters.
In studies of experimental Lyme disease, a major obstacle has been the unavailability of a suitable animal model. We found that irradiated LSH/Ss Lak hamsters developed arthritis after injection of Borrelia burgdorferi in the hind paws. When nonirradiated hamsters were injected in the hind paws with B. burgdorferi, acute transient synovitis was present. A di
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9. Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.
We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To examine whether the induction of apoptosis caused by anti-Fas mAb may play a potential role as a new therapeutic strategy for RA, we investigated the effect of anti-F
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10. Long term follow up of SHR rats with experimental yersinia associated arthritis.
One hundred and one SHR rats were injected intravenously with live Yersinia enterocolitica O:8. The rats were randomly divided into two groups consisting of 48 and 53 rats. The group of 48 rats was monitored for 245 days to establish the incidence and the clinical features of the arthritis. The remaining 53 rats were killed in groups of three to five rats at
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11. Effect of a specific iron chelating agent on animal models of inflammation.
Iron is an important catalyst of oxidative radical reactions and promotes the formation of the hydroxyl radical from the superoxide anion radical and hydrogen peroxide. The stimulatory effect of the hydroxyl radical on lipid peroxidation prompted the speculation that free iron may directly promote inflammation and that iron chelating agents may have useful a
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12. Effect of three animal models of inflammation on nerve fibres in the synovium.
OBJECTIVES--Both sensory and sympathetic nerve fibres are depleted in the synovium in rheumatoid arthritis (RA). The hypothesis that the induction of an inflammatory response in the synovium is capable of causing depletion of nerve fibres was tested. METHODS--To investigate this phenomenon experimental arthritis in the rat was induced by three different meth