Tape Stripping
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Evaluation of skin absorption of drugs from topical and transdermal formulations
ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal f
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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2. Basic considerations in the dermatokinetics of topical formulations
A avaliação da biodisponibilidade de moléculas de fármacos no sítio de ação oferece melhor compreensão sobre a eficiência da forma de dosagem. Entretanto, a determinação da concentração de fármaco nas camadas da pele em seguida à aplicação tópica de formulações dermatológicas é um grande desafio. Os protocolos seguidos para as formulaç
Braz. J. Pharm. Sci.. Publicado em: 2013-09
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3. Avaliação da quantidade e uniformidade do filtro solar quando aplicado na pele de adolescentes e adultos jovens após aplicação simples e reaplicação, através da técnica de tape-stripping
Introdução: o fator de proteção solar (FPS) dos filtros solares é determinado in vivo pela aplicação de uma quantidade padrão de 2mg/cm². Na prática, os usuários aplicam uma quantidade menor e de maneira irregular o que afeta o FPS final. Modelos matemáticos mostram que a reaplicação do fotoprotetor resulta em um aumento de 15-40% na capacidade
Publicado em: 2010
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4. Avaliação da penetração cutânea de nanocápsulas de isotretinoína por tape stripping in vitro em pele humana e suína / Assessment of cutaneous penetration of isotretinoin-loaded nanocapsules by tape stripping in vitro in human and pig skin
Objetivos: objetivo geral deste trabalho foi avaliar a penetração cutânea da isotretinoína nanoencapsulada e livre utilizando técnicas de microdiálise e tape stripping in vitro. Métodos: A viabilidade da utilização da técnica de microdiálise para avaliar o perfil farmacocinético da isotretinoína após aplicação tópica foi investigada através
Publicado em: 2009
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5. Desenvolvimento de sistemas de liberação para a administração tópica passiva e iontoforética do minoxidil no tratamento da alopecia androgênica / Development of delivery systems for the topical passive and iontophoretic administration of minoxidil for the androgenic alopecia treatment
Given the hypothesis that polymeric microparticles can penetrate the skin barrier along the transfollicular route, and based on the evidence that iontophoresis is a method that can direct the delivery of drugs to the hair follicles, this work aimed to study the in vitro skin permeation of minoxidil sulfate (MXS), a drug used to treat androgenic alopecia, bot
Publicado em: 2009
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6. Formas farmacêuticas plásticas contendo nanocápsulas, nanoesferas e nanoemulsões de nimesulida: desenvolvimento, caracterização e avaliação da permeação cutânea in vitro / Semi-solids dosage forms containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: development, characterization and in vitro percutaneous permeation evaluation
O objetivo deste trabalho foi desenvolver e caracterizar formulações tópicas semi-sólidas, utilizando como substância ativa a nimesulida, associando-a a sistemas coloidais (nanoesferas, nanocápsulas ou nanoemulsões). Os parâmetros de liberação, penetração transcutânea e retenção cutânea do antiinflamatório veículado aos sistemas nanoestrutu
Publicado em: 2007
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7. Avaliação da influência de tensoativos na pele de muda de cobra (Bothrops jararaca e Spilotis pullatus) por espectroscopia fatoacústica no infravermelho, calorimetria exploratória diferencial e espectroscopia Raman / Evaluation of the influence of surfactants on the stratum corneum of shed snake skin (Bothrops jararaca and Spilotis pullatus) by photoacoustic spectroscopy, differential scanning calorimetry and Raman spectroscopy
The influence of the surfactants sodium lauryl sulfate, cetyl trimethyl ammonium chloride and lauryl alcohol ethoxylate (12 moles ethylene oxide) was evaluated on the stratum corneum of shed snake skin (Bothrops jararaca and Spilotis pullatus) through the biophysical techniques PAS-FTIR, FT-Raman and DSC. The surfactants were used in solutions above and belo
Publicado em: 2004
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8. Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.
The disruption of the cutaneous permeability barrier results in metabolic events that ultimately restore barrier function. These include increased epidermal sterol, fatty acid, and sphingolipid synthesis, as well as increased epidermal DNA synthesis. Because tumor necrosis factor (TNF) and other cytokines are known products of keratinocytes and have been sho
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9. In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum.
A direct study evaluating whether differential drug uptake of topical 2% miconazole and 2% ketoconazole from cream formulations into human stratum corneum correlated with differential pharmacological activity against Candida albicans was investigated in healthy human subjects. A single 24-h topical dose of 2% ketoconazole cream or 2% miconazole cream was app
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10. Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis
H-2Kb-restricted tumor epitope peptides, including tyrosinase-related protein 2 residues 181–188 (TRP-2) and connexin 37 residues 52–59 (MUT1), were applied to permeability barrier-disrupted C57BL/6 (B6) mouse skin from which the stratum corneum of the epidermis had been removed by tape-stripping. This procedure primed tumor-specific cytotoxic T lymphocy
The National Academy of Sciences.
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11. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.
Aged epidermis displays altered drug permeability, increased susceptibility to irritant contact dermatitis, and often severe xerosis, suggesting compromise of the aged epidermal barrier. To delineate the functional, structural, and lipid biochemical basis of epidermal aging, we compared barrier function in young (20-30 yr) vs aged (> 80 yr) human subjects, a
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12. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis
We found that mechanical injury to mouse skin, which can be caused by tape stripping, results in rapid induction of IL-10 mRNA. IL-10–/– mice were used to examine the role of IL-10 in a mouse model of allergic dermatitis induced by epicutaneous (EC) sensitization with OVA on tape-stripped skin. Skin infiltration by eosinophils and expression of eotaxin,
American Society for Clinical Investigation.