Tetracaine
Mostrando 1-12 de 65 artigos, teses e dissertações.
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1. Liberação fracional de Ca2+ no modelo do retículo sarcoplasmático funcionalmente isolado : experimentação e modelamento matemático / Fractional Ca2+ release in the model of the functionally isolated sarcoplasmic reticulum : experimentation and mathematical modeling
A fração do conteúdo de Ca2+ do retículo sarcoplasmático (RS) liberada a cada contração (Fractional Release - FR) em miócitos cardíacos é regulada pela corrente de entrada de Ca2+ através da membrana celular pelos canais de Ca2+ tipo-L (ICa,L) e pelo conteúdo de Ca2+ do RS ([Ca2+]RS). Em trabalho anterior foi desenvolvido, no nosso laboratório,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2011
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2. Avaliação de formulações anestésicas de tetracaína em beta-ciclodextrina e hidroxipropil beta-ciclodextrina / Evaluation of tetracaine anesthetic formulations in beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin
A dor desempenha um papel biológico muito importante como indicador da presença de um estímulo nocivo, que pode representar dano real ou potencial ao organismo; entretanto, não é interessante que essa sinalização persista além das necessidades fisiológicas a ponto de tornar-se um incomodo, podendo dificultar o desempenho das atividades normais, comp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/02/2010
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3. Interação dos anestesicos locais benzocaina, lidocaina e tetracaina com membranas modelo
Among the theories for the mecanism of action of local anesthetics (LA) we can highlight those explaining LA effects upon the sodium channel protein and those which focus on the effects of LA interaction with the lipid membrane phase. Once a direct correlation among LA hydrophobicity (measured by the partition coefficient) and its clinical potency exists, it
Publicado em: 1998
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4. The differential effects of twitch potentiators on charge movements in frog skeletal muscle.
The effects of twitch potentiators at physiologically effective concentrations on intramembrane charge movements were examined in voltage-clamped frog skeletal muscle in the presence and absence of tetracaine. Caffeine, even at high concentrations (2.5 mM) did not alter the potential dependence of either tetracaine-sensitive or tetracaine-resistant portions
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5. The effect of tetracaine on spontaneous Ca2+ release and sarcoplasmic reticulum calcium content in rat ventricular myocytes.
1. The effects of tetracaine were studied on voltage-clamped rat ventricular myocytes, which exhibited Ca2+ overload as identified by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) as shown by the associated contractions. This Ca2+ release was initially abolished by tetracaine before returning at a lower frequency, but greater amplitude, than
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6. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes.
1. Confocal microfluorometry was used to study the effects of tetracaine on spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) in isolated rat ventricular myocytes. 2. At low concentrations (0.25-1.25 mM), tetracaine caused an initial inhibition of spontaneous release events (Ca2+ sparks) and Ca2+ waves, which was followed by a gradual increase in
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7. Charged tetracaine as an inactivation enhancer in batrachotoxin-modified Na+ channels.
Two distinct types of local anesthetics (LAs) have previously been found to block batrachotoxin (BTX)-modified Na+ channels: type 1 LAs such as cocaine and bupivacaine interact preferentially with open channels, whereas type 2 LAs, such as benzocaine and tricaine, with inactivated channels. Herein, we describe our studies of a third type of LA, represented b
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8. Differential effects of tetracaine on two kinetic components of calcium release in frog skeletal muscle fibres.
1. Intramembrane charge movements and changes in intracellular calcium concentration were recorded simultaneously in voltage clamped cut skeletal muscle fibres of the frog in the presence and absence of tetracaine. 2. Extracellular application of 20 microM tetracaine reduced the increase in myoplasmic [Ca2+]. The effect on the underlying calcium release flux
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9. Dual actions of tetracaine on intramembrane charge in amphibian striated muscle.
1. The effects of graded concentrations of tetracaine on the steady-state and kinetic properties of intramembrane charge were examined in intact voltage-clamped amphibian muscle fibres. 2. The micromolar tetracaine concentrations that were hitherto reported to abolish Ca2+ transients in skeletal muscle failed to affect significantly the steady-state charge.
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10. The effects of tetracaine on the membrane currents and contraction of frog atrial muscle.
1. The effects of tetracaine on the membrane currents and contraction of isolated frog atrial trabeculae under voltage clamp has been investigated. 2. Tetracaine inhibits the slow inward current in a competitive way with a Ki of 0.13 mM, and the phasic component of the contractile response in a non-competitive manner with a Ki of 0.25 mM. 3. The tonic phase
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11. The effects of tetracaine on charge movement in fast twitch rat skeletal muscle fibres.
1. The effects of tetracaine, a local anaesthetic that inhibits muscle contraction, on membrane potential and intramembrane charge movements were investigated in fast twitch rat muscle fibres (extensor digitorum longus). 2. The resting membrane potentials of surface fibres from muscles bathed in isotonic Ringer solution containing 2 mM-tetracaine were well m
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12. Differential effects of ryanodine and tetracaine on charge movement and calcium transients in frog skeletal muscle.
1. Charge movement and myoplasmic calcium transients were simultaneously recorded from frog skeletal muscle fibres by using the double-seal Vaseline-gap technique. Calcium transients were monitored with the fluorescent indicator Rhod-2. 2. Ryanodine modified the kinetics and the total amount of charge moved during depolarizing pulses (Q(on)), while it did no