Therapeutical Targets
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Angiogênese, células-tronco neoplásicas CD34+ e sinvastatina em modelo de carcinogênese mamária induzida quimicamente / Angiogenesis, CD34+ cancer stem-cells and simvastatin in a chemically induced mammary carcinogenesis model
Breast cancer is the most common malignancy and the leading cause of death from cancer among females worldwide. Despite all the research and all the progress achieved so far, the morbidity and mortality due to this cancer remains high in patients at advanced stages. Recently, it was described a new model of carcinogenesis in which stem cells (SC) could be re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/02/2012
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2. Melatonin effect on the endothelial nitric oxide production in vitro and in vivo / Efeito da melatonina sobre a produção endotelial de óxido nítrico in vitro e in vivo
Melatonin, the darkness hormone, produced at night by the pineal gland, is also synthesized in a non-rhythmic manner by other cells. Pineal and extra-pineal melatonin reaches endothelial layer, and the understanding of its mechanism of action will improve the possibilities of using this indolamine and derivates as pharmacological tools. Here we showed that m
Publicado em: 2009
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3. Aumento da IL-1beta no processo de arterialização de enxertos venosos utilizando modelos ex vivo, in vitro e in vivo / Increased IL-1beta during vein grafts arterialization: study of ex vivo, in vitro and in vivo models
The vein graft is subjected to increased tensile stress and the complex adaptive vein response to the arterial hemodynamic condition may predispose to bypass failure in some individuals. The understanding of molecular changes underlying this process may be useful for the development of novel therapeutical interventions to increase the vein graft patency. In
Publicado em: 2008
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4. Alvos Terapêuticos Para o Tratamento Psicológico da Fibromialgia / Therapeutical targets for the psychological treatment of the Fibromyalgia.
A Fibromialgia é uma síndrome dolorosa crônica que vem associada a uma variedade de sintomas e queixas subjetivas relacionadas à exacerbação e manutenção da dor. Esta complexidade não é levada em conta, de forma integrada, nos modelos de tratamento para dor crônica. Geralmente as intervenções tomam como alvo um aspecto isolado da dor, como a fun
Publicado em: 2007
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5. Estudo da relevância fisiológica da tioesterase humana II (hTE) na modulação de CD4 mediada pela proteína Nef do HIV 1
The down-modulation of CD4 receptor expression is one of the most important events during the HIV-1 infection. Among the three viral proteins involved in this process Nef, Env and Vpu, the first one is the most relevant. Results obtained by our group and others showed a clear relationship between the virus mediated receptor down-modulation, the increasing of
Publicado em: 2007
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6. Genoma funcional e análise "in silico" na caracterização e no isolamento de genes envolvidos em gliomas humanos / Caracterization and isolation of genes involved in human gliomas by functional genome and in silico anlysis
Gliomas are the most fatal central nervous system tumors and to date, satisfactory results from chemotherapies or surgical interventions are still not available. The ST1 rat glioma cell line is hyper-responsive to treatment with glucocorticoids (GC), undergoing a complete tumoral to normal phenotypic reversion, both in vitro and in vivo. The P7 glioma cell l
Publicado em: 2006