Three Dimensional Cellular Models
Mostrando 1-9 de 9 artigos, teses e dissertações.
-
1. A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay
Current therapy for pancreatic cancer is multimodal, involving surgery and chemotherapy. However, development of pancreatic cancer therapies requires a thorough evaluation of drug efficacy in vitro before animal testing and subsequent clinical trials. Compared to two-dimensional culture of cell monolayer, three-dimensional (3-D) models more closely mimic nat
Braz J Med Biol Res. Publicado em: 22/07/2013
-
2. Estudo dos efeitos da terapia fotodinâmica na progressão tumoral e em modelos celulares tridimensionais / Study of the effects of photodynamic therapy on tumor progression and in three-dimensional cellular models.
Melanoma is the type of skin cancer with poor prognosis due to its high probability of suffering metastases. Currently there are few effective treatments for the this, and the survival of patients with metastases is very low, around 8 months, with cure rates of these conditions do not exceed 1%. Photodynamic therapy (PDT) is a therapeutic modality selective
Publicado em: 2010
-
3. Comparative evaluation of the anatomical development of the temporomandibular joint, by means of magnetic resonance, digital econstruction and histological sections. / "Avaliação comparativa da anatomia do desenvolvimento da articulação temporomandibular, por meio do uso de ressonância magnética, reconstrução digital e cortes histológicos"
The present study was carried out to evaluate the effectiveness of Magnetic Resonance Imaging (MRI) and bi and three-dimensional digital reconstructions of the TMJ in different stages of development, by the comparison with histological sections. A proper protocol of IRM examination was developed, which was applied in formalin-preserved human embryos and fetu
Publicado em: 2005
-
4. Proposed three-dimensional structure for the cellular prion protein.
Prion diseases are a group of neurodegenerative disorders in humans and animals that seem to result from a conformational change in the prion protein (PrP). Utilizing data obtained by circular dichroism and infrared spectroscopy, computational studies predicted the three-dimensional structure of the cellular form of PrP (PrPc). A heuristic approach consistin
-
5. A 3D Hybrid Model for Tissue Growth: The Interplay between Cell Population and Mass Transport Dynamics
To provide theoretical guidance for the design and in vitro cultivation of bioartificial tissues, we have developed a multiscale computational model that can describe the complex interplay between cell population and mass transport dynamics that governs the growth of tissues in three-dimensional scaffolds. The model has three components: a transient partial
The Biophysical Society.
-
6. A three-dimensional model of myxobacterial aggregation by contact-mediated interactions
Myxobacteria provide one of the simplest models of cell–cell interaction and organized cell movement leading to cellular differentiation. When starved, tens of thousands of cells change their movement pattern from outward spreading to inward concentration; they form aggregates that become fruiting bodies. Cells inside fruiting bodies differentiate into rou
National Academy of Sciences.
-
7. Ovol2 Suppresses Cell Cycling and Terminal Differentiation of Keratinocytes by Directly Repressing c-Myc and Notch1*
Ovol2 belongs to the Ovo family of evolutionarily conserved zinc finger transcription factors that act downstream of key developmental signaling pathways including Wg/Wnt and BMP/TGF-β. We previously reported Ovol2 expression in the basal layer of epidermis, where epidermal stem/progenitor cells reside. In this work, we use HaCaT human keratinocytes to inve
American Society for Biochemistry and Molecular Biology.
-
8. Predicting ligand-binding function in families of bacterial receptors
The three-dimensional fold of a new protein sequence can often be inferred directly from sequence homology to a protein of known structure. The function of a new protein sequence is more difficult to predict, however, since homologues can have different molecular and cellular functions. To develop and automate computational methods for determining molecular
The National Academy of Sciences.
-
9. Structure of Recombinant Rabies Virus Nucleoprotein-RNA Complex and Identification of the Phosphoprotein Binding site
Rabies virus nucleoprotein (N) was produced in insect cells, in which it forms nucleoprotein-RNA (N-RNA) complexes that are biochemically and biophysically indistinguishable from rabies virus N-RNA. We selected recombinant N-RNA complexes that were bound to short insect cellular RNAs which formed small rings containing 9 to 11 N monomers. We also produced re
American Society for Microbiology.