Thyroid Anaplastic Carcinoma
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Dramatic clinical response to dabrafenib plus trametinib in anaplastic thyroid carcinoma and the challenges faced during the COVID-19 pandemic
SUMMARY Anaplastic thyroid carcinoma is the rarest tumor of the thyroid gland, representing less than 2% of clinically recognized thyroid cancers. Typically, it has an extremely rapid onset, fatal outcomes in most cases, and a median overall survival of 3 to 10 months despite aggressive multidisciplinary management. The presence of targetable mutations in an
Arch. Endocrinol. Metab.. Publicado em: 2021-04
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2. Irisin and its relationship with metabolic health: more questions than answers
SUMMARY Anaplastic thyroid carcinoma is the rarest tumor of the thyroid gland, representing less than 2% of clinically recognized thyroid cancers. Typically, it has an extremely rapid onset, fatal outcomes in most cases, and a median overall survival of 3 to 10 months despite aggressive multidisciplinary management. The presence of targetable mutations in an
Arch. Endocrinol. Metab.. Publicado em: 2021-04
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3. EIF1AX c.338-2A>T splice site mutation in a patient with trabecular adenoma and cytological indeterminate lesion
SUMMARY The EIF1AX gene mutations have been recently associated with papillary thyroid carcinoma and anaplastic thyroid cancer. According with these reports, the gene as been considered as a drive gene for thyroid cancer development. However, the occurrence of these alterations in benign thyroid lesions is not known and is still under investigation. Some aut
Arch. Endocrinol. Metab.. Publicado em: 2020-04
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4. Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital
ABSTRACT Objective The aim of the present study was to describe the epidemiologic data, histological type, treatment and follow-up of the 811 patients treated for thyroid cancer in Instituto do Câncer do Estado de São Paulo (ICESP) over 5 years. Materials and methods Retrospective analyses of electronic chart information. Results There were 679 cases
Arch. Endocrinol. Metab.. Publicado em: 10/10/2016
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5. Study of Arkadia expression, ubiquitination E-3 protein, in thyroid tumors and its relation to the TGF-beta signaling pathway. / Estudo da expressão de Arkadia, proteína E3 de ubiquitinação, em tumores de tiróide e sua relação com a via de sinalização de TGF-Beta.
Arkadia participa do processo de amplificação da sinalização de TGF-b mediada por Smads, via degradação do I-Smad. O objetivo desse estudo foi caracterizar e investigar a influência de Arkadia em linhagens celulares de cânceres de tiróide. A expressão gênica de Arkadia em linhagens celulares de carcinomas papílifero (NPA), folicular (WRO) e anapl
Publicado em: 2009
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6. Avaliação de prognostico do carcinoma de tireoide atraves de marcadores imunoistoquimicos / Evaluation of prognostic of the thyroid carcinoma through immunohistochemical markers
Because most differentiated thyroid carcinomas have an excellent prognosis, some authors have been claiming that these patients have been over-treated. Combinations of patient-and tumor-specific factors have been proposed for prognostic stratification, but no clinicpathologic staging was demonstrated to be useful at the present time. In order to investigate
Publicado em: 2006
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7. Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors
In addition to the mutations that underlie most cases of the multiple endocrine neoplasia type 1 (MEN1) syndrome, somatic mutations of the MEN1 gene have also been described in sporadic tumors like gastrinomas, insulinomas and bronchial carcinoid neoplasm. We examined exon 2 of this gene, where most of the mutations have been described, in 148 endocrine and
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-07
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8. p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas.
AIM--To study the expression of p53 tumour suppressor gene in anaplastic carcinomas arising from thyroid papillary carcinomas. METHODS--Formalin fixed, paraffin wax embedded tissues from four cases of anaplastic carcinomas associated with thyroid papillary carcinomas were studied by immunohistochemistry with two different p53 monoclonal antibodies. RESULTS--
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9. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
The development and progression of thyroid tumors is signaled by phenotype-specific mutations of genes involved in growth control. Molecular events associated with undifferentiated thyroid cancer are not known. We examined normal, benign, and malignant thyroid tissue for structural abnormalities of the p53 tumor suppressor gene. Mutations were detected by si
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10. Hürthle cell follicular carcinoma of the thyroid gland presenting with diffuse meningeal carcinomatosis and evolving to anaplastic carcinoma
BMJ Group.
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11. Epidermal growth factor receptor status in anaplastic thyroid carcinoma
BMJ Group.
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12. Cytotoxic effects of Gemcitabine-loaded liposomes in human anaplastic thyroid carcinoma cells
BioMed Central.