Toxicokinetic
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. CONVULSIVE ACTION OF DIPHENYL DISELENIDE IN RATS: STUDY OF THE NEUROCHEMISTRY MECHANISMS AND TOXICOKINETIC / AÇÃO CONVULSIVANTE DO DISSELENETO DE DIFENILA EM RATOS: ESTUDO DOS MECANISMOS NEUROQUÍMICOS E DA TOXICOCINÉTICA
Nos últimos anos, têm sido identificadas inúmeras propriedades farmacológicas do composto de selênio disseleneto de difenila [(PhSe)2]. Assim, a pesquisa dos efeitos tóxicos deste composto torna-se importante para a segurança na aplicação farmacológica. Sabe-se que os bebês, em particular, apresentam muitas mudanças fisiológicas e bioquímicas r
Publicado em: 2010
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2. Toxicity of cyanide in swine: evaluation of perinatal effects / Toxicidade do cianeto em suínos. Avaliação dos efeitos perinatais
Cyanide and cyanogenic compounds are ubiquitous in nature and widely studied in toxicology. Long-term cyanide exposure has been associated to development of goiter, pancreatic diabetes, and several neurological diseases in humans and animals. However, the exact mechanism involved in induction of these diseases are not fully elucidated. It is believed that th
Publicado em: 2006
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3. Case report: Survival after deliberate strychnine self-poisoning, with toxicokinetic data
BioMed Central.
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4. Variability in biological monitoring of solvent exposure. I. Development of a population physiological model.
Biological indicators of exposure to solvents are often characterised by a high variability that may be due either to fluctuations in exposure or individual differences in the workers. To describe and understand this variability better a physiological model for differing workers under variable industrial environments has been developed. Standard statistical
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5. Benzene toxicokinetics in humans: exposure of bone marrow to metabolites.
A three compartment physiologically based toxicokinetic model was fitted to human data on benzene disposition. Two separate groups of model parameter derivations were obtained, depending on which data sets were being fitted. The model was then used to simulate five environmental or occupational exposures. Predicted values of the total bone marrow exposure to