Toxicology In Rats
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Production, characterization and toxicology assay of creatine pegylated nanoliposome with polysorbate 80 for brain delivery
ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nano
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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2. Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats
Copaiba oil, extracted from Copaifera multijuga Hayne, Fabaceae, is widely used for medicinal purposes, especially to treat inflammatory processes. However, there is no report regarding its effect on reproductive performance after used in repeated doses orally. The present study evaluated the effects of the oral administration of Copaiba oil (at doses of 200
Rev. bras. farmacogn.. Publicado em: 2014-06
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3. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Publicado em: 2010
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4. Estudo dos efeitos toxicológicos em ratos Wistar alimentados com ração contendo Urânio. / Study of toxicological effects in Wistar rats fed with uranium.
O urânio (U) é um elemento tóxico radioativo encontrado na natureza, normalmente presente na água e nos alimentos e acumula-se preferencialmente em ossos. Nestes, a medula óssea constitui o alvo com o maior risco radiobiológico. Foram utilizados 60 ratos wistar recém desmamados, com vinte e dois dias de vida. Destes, trinta e cinco foram tratados com
Publicado em: 2010
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5. Avaliação dos efeitos imunotóxicos da Ipomoea carnea e de seu princípio ativo tóxico, a suainsonina, em ratos jovens e adultos / Evaluation of the immunotoxic effects of Ipomoea carnea and its toxic principle, the swainsonine in young and adult rats
O presente estudo visou avaliar os efeitos da administração do resíduo aquoso final (RAF) da Ipomoea carnea e da suainsonina, sobre o sistema imune de ratos jovens em idade pré-pubere (21 dias) e adultos (70 dias). Para isso, o RAF foi administrado nas doses de 1,0; 3,0 e 7,0 g/kg e a suainsonina na dose de 5,0 mg/kg, por gavage, durante 14 dias para ava
Publicado em: 2010
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6. Efeito da exposição crônica ao níquel nos testículos de ratos Wister adultos / Effect of chronic nickel exposure in the testes of Wistar adult rats
A toxicidade de um metal depende da sua capacidade inerente de afetar adversamente qualquer atividade biológica. Entre poluentes ambientais, o níquel, um metal pesado, merece destaque especial como um elemento potencialmente tóxico. A exposição aguda ou crônica ao níquel resulta em vários efeitos na reprodução, tendo como alvo o testículo, que é
Publicado em: 2010
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7. Estudo da toxicidade da Ipomoea carnea em ratas durante o período perinatal. Avaliação dos possíveis efeitos lesivos no tecido placentário / Ipomoea carnea toxicity study in rats during perinatal period. Evaluation of possible harmful effects on the placental tissue
A Ipomoea carnea é uma planta tóxica amplamente distribuída no Brasil e em outros países tropicais. Durante os períodos de seca esta planta se mantém verde, podendo servir como fonte de alimento para os animais de produção. A intoxicação natural é de caráter crônico e ocorre quando ruminantes particularmente, caprinos ingerem a planta, estes ani
Publicado em: 2009
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8. Estudo dos mecanismos de ação da hidroquinona e fenol sobre o recrutamento leucocitário em respostas inflamatórias / Study of mechanisms of action of hydroquinone and phenol on leukocyte recruitment in inflammatory response
Hydroquinone (HQ) is one of the metabolites of benzene responsible for the toxic effects of exposure to solvent, as well as being part of the diet, medicines, tobacco and polluting the environment. Considering the immunotoxicity of this substance, our laboratory has investigated the role of exposure to HQ by prolonged period of time on acute inflammatory res
Publicado em: 2008
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9. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Brazilian Journal of Medical and Biological Research. Publicado em: 21/08/2007
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10. AvaliaÃÃo toxicolÃgica reprodutiva do fitoterÃpico sanativoÂ
The effects of the administration of Sanativo (SAN) were investigated on the pregnancy in Wistar rats. Four groups of female rats (5-8/group) were treated orally with SAN (67, 335 and 1675mg/kg) or water during the pregnancy period (1st to the 21st day) and during each one of the two first phases of pregnancy: pre-implantation (1st to the 6th day) and orga
Publicado em: 2007
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11. AvaliaÃÃo toxicolÃgica prÃ-clÃnica do Ãleo de Carapa guianensis Aublet.
Carapa guianensis (Meliaceae), a typical tree from amazon region, is popularly known as Andiroba. Its seed oil is used as anti-inflammatory, analgesic and insect repellent. Although C. guianensis is largely used by people, there are no studies concerning its toxicity. In this way, the aim of this work was to evaluate the safety of the C. guianensis seed oil
Publicado em: 2006
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12. AVALIAÇÃO TOXICOLÓGICA CRÔNICA DO POLÍMERO QUITOSANA FERRO(III) SOLÚVEL / CHRONIC TOXICOLOGY AVALIATION OF SOLUBLE IRON (III) CHITOSAN
Hyperphosphatemia is a common problem in patients with chronic renal failure, particularly in those who have reached end-stage renal diseased. The main methods of achieving control of the increased of phosphate are reduction of dietary intake, reduction of gastrointestinal absorption by use of binding agents and removal by dialysis. In this study, we evaluat
Publicado em: 2006