Transforming Growth Factos Beta
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1. Myofibroblasts are frequent in the stroma and invasive front of oral squamous cell carcinomas where they control the tumoral behavior by stimulating cellular proliferation and matrix metalloproteinase 2 activity of the tumor cells / Miofibroblastos são frequentes no estroma e no fronte invasivo dos carcinomas espinocelulares orais onde controlam o comportamento tumoral por estimular a proliferação celular e a atividade da metaloproteinase de matriz 2 das celulas tumorais
Myofibroblasts are characterized by the expression of elevated amounts of growth factors, proteases and extracellular matrix, which may influence the tumor progression. Recent studies have detected myofibroblasts in the stroma of several tumors, including those of breast, kidney, liver, bladder, colon and prostate, being the presence of those cells associate
Publicado em: 2007