Transgenic Mouse
Mostrando 1-12 de 1381 artigos, teses e dissertações.
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1. An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis
Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disease models was the development of gene editing technique
Braz J Med Biol Res. Publicado em: 25/04/2019
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2. Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair
Abstract Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used. However, these surgical techniques result in nerve regeneration at highly variable degrees. It is thus very importa
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/05/2018
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3. Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease
BACKGROUND Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects in the heart are unknown. Reports have
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-08
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4. Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology
Cardiac remodeling involves changes in heart shape, size, structure, and function after injury to the myocardium. The proinflammatory adaptor protein myeloid differentiation protein 88 (MyD88) contributes to cardiac remodeling. To investigate whether excessive MyD88 levels initiate spontaneous cardiac remodeling at the whole-organism level, we generated a tr
Braz J Med Biol Res. Publicado em: 27/11/2015
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5. Regulação do desenvolvimento e determinação do fruto de tomateiro (Solanum lycopersicum) pela via microRNA156/ SQUAMOSA Promoter-Binding Protein-Like (SPL) / MiR156targeted Squamosa Promoter-binding proteins (SPLs) regulate fruit development and determinacy
Many plants have indeterminate growth and are capable of producing new organs and tissues throughout their life. This capability is partially due to the highly regulated expression of specific genes such as SQUAMOSA Promoter-Binding Protein-Like (SPL) genes. SPLs encode plant-specific transcription factors that play important roles in development, such as ph
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/04/2012
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6. Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles (containing hyperphosphorylated Tau protein), along with neu
Clinics. Publicado em: 2011
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7. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors
The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium handling (Na+/K+-ATPase and Ca2+-ATPases) and growth (ERK1/2, JNK1/2 and p38) in mice with cardiac-selective overexpression of constitutivel
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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8. Effect of aging and oral tolerance on dendritic cell function
Oral tolerance can be induced in some mouse strains by gavage or spontaneous ingestion of dietary antigens. In the present study, we determined the influence of aging and oral tolerance on the secretion of co-stimulatory molecules by dendritic cells (DC), and on the ability of DC to induce proliferation and cytokine secretion by naive T cells from BALB/c and
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
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9. Efeitos da deleção do gene Cx43 sobre o desenvolvimento fetal de camundongos de diferentes backgrounds genéticos: ênfase na osteogênese / Effects of Cx43 gene deletion on mouse fetal development in different genetics backgrounds: Emphasis in osteogenesis
Conexinas são proteínas que compõem as junções comunicantes do tipo gap, e a diminuição na sua expressão tem sido relacionada com diversas alterações fisiológicas, entre elas algumas síndromes, malformações genéticas, o aumento da proliferação celular e a carcinogênese. Dentre as isoformas das conexinas presentes nos tecidos animais, a Cx43
Publicado em: 2009
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10. Comparative mitochondrial proteome : an analysis of transgenic hipertriglyceridemic mouse in contrast with normal triglyceridemic mouse / Proteoma comparativo de mitocondria : uma analise de camundongo transgenico hipertrigliceridemico versus camundongo normo trigliceridemico
A proteômica tem-se tomado ao longo dos últimos anos uma área de estudo cada vez mais essencial para o melhor entendimento dos mecanismos efetores e regulatórios das células e suas interações em sistemas biológicos. Patologias de origem genética como a hipertrigliceridemia, que geralmente modificam o perfil lipídico com o aumento dos níveis de tri
Publicado em: 2009
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11. Effect of a high fat diet on mitochondria: bioenergetics, K+ transport and redox state / Efeito de dietas hiperlipídicas sobre mitocôndrias de fígado de camundongos: bioenergética, transporte de K+ e estudo redox
Obesity is associated with multiple dysfunctions including dyslipidemia, insulin resistance and diabetes. These malfunctions are associated with modifications in mitochondrial physiology. Furthermore, mitochondria are the most important site of energy metabolism and reactive oxygen species production. Alberici et al. (2006) demonstrated that hypertriglycerid
Publicado em: 2009
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12. Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model
Acute promyelocytic leukemia (APL) is characterized by the expansion of blasts that resemble morphologically promyelocytes and harbor a chromosomal translocation involving the retinoic acid receptor a (RARa) and the promyelocytic leukemia (PML) genes on chromosomes 17 and 15, respectively. The expression of the PML/RARa fusion gene is essential for APL genes
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-05