Transient Cerebral Ischemia
Mostrando 1-12 de 39 artigos, teses e dissertações.
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1. Protective Effects of Adrenomedullin on Rat Cerebral Tissue After Transient Bilateral Common Carotid Artery Occlusion and Reperfusion
Abstract Objective: We aimed to investigate the protective effect of adrenomedullin (ADM) on cerebral tissue of rats with cerebral ischemia/reperfusion (I/R) injury. Methods: Thirty-two Wistar rats were randomized into four groups (n=8). In the I/R Group, bilateral common carotid arteries were clamped for 30 minutes and, subsequently, reperfused for 120 mi
Braz. J. Cardiovasc. Surg.. Publicado em: 2020-06
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2. Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion
Abstract Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemi
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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3. The role of histone deacetylase inhibitors in regulation of Akt/GSK-3β signaling pathway in mice following transient focal cerebral ischemia
Abstract Purpose: To investigate whether the neuroprotective effect of TSA on cerebral ischemia reperfusion injury is mediated by the activation of Akt/GSK-3β signaling pathway. Methods: Mice were randomly divided into four groups (n=15): sham group (S); ischemia reperfusion group (IR); ischemia reperfusion and pretreated with TSA group (IR+T); ischemia
Acta Cir. Bras.. Publicado em: 2017-10
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4. Physical exercise prevents motor disorders and striatal oxidative imbalance after cerebral ischemia-reperfusion
Stroke is the third most common cause of death worldwide, and most stroke survivors present some functional impairment. We assessed the striatal oxidative balance and motor alterations resulting from stroke in a rat model to investigate the neuroprotective role of physical exercise. Forty male Wistar rats were assigned to 4 groups: a) control, b) ischemia, c
Braz J Med Biol Res. Publicado em: 28/07/2015
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5. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice
OBJECTIVE: Ischemic stroke may result from transient or permanent reductions of regional cerebral blood flow. Polymorphonuclear neutrophils have been described as the earliest inflammatory cells to arrive in ischemic tissue. CXCR1/2 receptors are involved in the recruitment of these cells. However, the contribution of these chemokine receptors during transie
Clinics. Publicado em: 2013
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6. Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery
Agmatine, an endogenous polyamine and putative neuromodulator, is known to have neuroprotective effects on various neurons in the central nervous system. We determined whether or not topically administered agmatine could reduce ischemic retinal injury. Transient ocular ischemia was achieved by intraluminal occlusion of the middle cerebral artery of ddY mice
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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7. Efeito neuroprotetor do prÃ-condicionamento por estresse de contensÃo sobre a lesÃo induzida por breve mudanÃa subcrÃtica isquÃmica: papel dos receptores A1 da adenosina. / Pre-conditioning induced by restraint stress provides protection against transient cerebral ischemia: Role of adenosine A1 receptors.
O acidente vascular cerebral, doenÃa incapacitante e terceira causa de morte em paÃses desenvolvidos à caracterizada pela interrupÃÃo ou reduÃÃo do fluxo sangÃÃneo para o cÃrebro capaz de causar alteraÃÃo na funÃÃo cerebral. Sabe-se que o receptor A1 da adenosina possui um papel chave na neuroproteÃÃo devido à diminuiÃÃo da liberaÃÃo de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/02/2009
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8. Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain
Chronic neurodegenerative processes have been identified in the rat forebrain after prolonged survival following hyperthermia (HT) initiated a few hours after transient global ischemia. Since transient global ischemia and ischemic penumbra share pathophysiological similarities, this study addressed the effects of HT induced after recirculation of focal brain
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-11
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9. L-deprenil previne alterações neuroquímicas e comportamentais induzidas pela isquemia cerebral transitória / L-Deprenyl prevines neurochemicals and comportamentals alterations induced of transiente cerebral ischaemia
The present work shows the effects of l-deprenyl (DEP, 5 and 10 mg/kg, po) on memory, as well as on rat brain free radical formation after transient cerebral ischemia (TCI). Wistar rats were anesthetized and submitted to TCI by occlusion of both carotid arteries for 20 minutes. In another experiment, animals were submitted to surgery without ischemia (sham-o
Publicado em: 2004
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10. Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia
Summary: Cumulative evidence suggests that apoptosis plays a pivotal role in cell death in vitro after hypoxia. Apoptotic cell death pathways have also been implicated in ischemic cerebral injury in in vivo ischemia models. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and the n
The American Society for Experimental NeuroTherapeutics.
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11. Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?
Ubiquitylated protein aggregates are characteristic features of neurodegenerative disorders that are also found in acute pathological states of the brain such as stroke. Many of the proteins connected to neurodegenerative diseases play a role in the ubiquitin-proteasomal pathway. Mutation of one of these proteins, the E3 ubiquitin ligase parkin, is the cause
National Academy of Sciences.
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12. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia
The MEK1 (MAP kinase/ERK kinase)/ERK (extracellular-signal-responsive kinase) pathway has been implicated in cell growth and differentiation [Seger, R. & Krebs, E. G. (1995) FASEB J. 9, 726–735]. Here we show that the MEK/ERK pathway is activated during focal cerebral ischemia and may play a role in inducing damage. Treatment of mice 30 min before ischemia
The National Academy of Sciences.