Trypanosoma Cruzi Like
Mostrando 1-12 de 66 artigos, teses e dissertações.
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1. Enveloped and non-enveloped viral-like particles in Trypanosoma cruzi epimastigotes
ABSTRACT Electron microscopy is routinely used to identify viral infections in protozoan parasites. These viruses have been described as non-enveloped and icosahedral structures with a diameter of 30-60 nm. Most of them are classified within the non-segmented dsRNA Totiviridae family. We observed virus-like particles (VLPs) through transmission electron micr
Rev. Inst. Med. trop. S. Paulo. Publicado em: 07/08/2017
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2. A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole
Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety of translocation processes and some members have been implicate
Mem. Inst. Oswaldo Cruz. Publicado em: 28/04/2015
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3. Induction of chagasic-like arrhythmias in the isolated beating hearts of healthy rats perfused with Trypanosoma cruzi-conditioned medium
Chagas' myocardiopathy, caused by the intracellular protozoan Trypanosoma cruzi, is characterized by microvascular alterations, heart failure and arrhythmias. Ischemia and arrythmogenesis have been attributed to proteins shed by the parasite, although this has not been fully demonstrated. The aim of the present investigation was to study the effect of substa
Braz J Med Biol Res. Publicado em: 11/01/2013
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4. Identificação de novos inibidores da enzima cruzaína de Trypanosoma cruzi candidatos a fármacos contra a doença de Chagas / Discovery of novel inhibitors of the cruzain enzyme from Trypanosoma cruzi as drug candidates against Chagas disease
A doença de Chagas, uma infecção parasitária amplamente distribuída na América Latina, é um problema grave de saúde pública com consequências devastadoras em termos de morbidade e mortalidade humana. O arsenal terapêutico contra a doença é bastante limitado e insuficiente em todos os aspectos clínicos. Visando o desenvolvimento de novos agentes
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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5. Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion
It has been recently shown that Trypanosoma cruzi trypomastigotes subvert a constitutive membrane repair mechanism to invade HeLa cells. Using a membrane extraction protocol and high-resolution microscopy, the HeLa cytoskeleton and T. cruzi parasites were imaged during the invasion process after 15 min and 45 min. Parasites were initially found under cells a
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-12
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6. Search for a platelet-activating factor receptor in the Trypanosoma cruzi proteome: a potential target for Chagas disease chemotherapy
Chagas disease (CD) causes the highest burden of parasitic diseases in the Western Hemisphere and is therefore a priority for drug research and development. Platelet-activating factor (PAF) causes the CD parasite Trypanosoma cruzi to differentiate, which suggests that the parasite may express PAF receptors. Here, we explored the T. cruzi proteome for PAF rec
Mem. Inst. Oswaldo Cruz. Publicado em: 2011-12
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7. In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy
Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity onTrypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibitory activity at 10 μg/mL (40.3 μM and 47.6 μM for hypnophilin and panepoxydone, respectively; ~100%), hypnophilin has a slightly greater inhibitory activity (
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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8. Tripanosomiasis americana: um estudo sobre a prevalência do Trypanosoma cruzi e Trypanosoma cruzi-like em roedores silvestres da provincia de San Luis, Argentina
INTRODUÇÃO: A doença de Chagas é causada pelo Trypanosoma cruzi e os mamíferos periantrópicos e silvestres mantêm o ciclo de infecção/transmissão, tanto no ambiente natural, como no peridomicílio. O objetivo deste trabalho foi mostrar os resultados de um estudo de roedores silvestres do centro e norte da Província de San Luis, Argentina, para ava
Revista da Sociedade Brasileira de Medicina Tropical. Publicado em: 2010-06
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9. Caracterização bioquímica de uma Leucil-aminopeptidase de Trypanosoma cruzi (LAPTc)
Pathogens depend on peptidase activities to accomplish many physiological processes, as well as to interact with their hosts, highlighting parasitic peptidases as virulence factors and, thus, potential drug targets. The kinetoplastid Trypanosoma cruzi genome sequencing, the aetiological agent of Chagas disease, has revealed 28 genes encoding putative aminope
Publicado em: 2010
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10. Proteínas quinases envolvidas na regulação do estresse em Trypanosoma. / Protein kinases involved in stress regulation in Trypanosoma.
Protozoa of the genus Trypanosoma have a complex life cycle alternating between vertebrate and invertebrate hosts. The adaptation to different environmental conditions requires rapid changes in gene expression to fill up the morphological and metabolic requirements for survival. Very little is known about the mechanisms that control these changes and the sig
Publicado em: 2010
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11. Análise bioquímica inicial do proteassoma em populações do Trypanosoma cruzi com diferentes fenótipos de resistência ao benzonidazol
Differences in susceptibility to benznidazole (Bz) and nifurtimox (NFX) among populations of Trypanosoma cruzi may explain, at least in part, the differences in efficacy of treatment of Chagas disease. The proteasome has an important role in the degradation of normal proteins, damaged, mutated, or denatured, including the degradation of regulatory proteins o
Publicado em: 2010
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12. α-N-acetylglucosamine-linked O-glycans of sialoglycoproteins (Tc-mucins) from Trypanosoma cruzi Colombiana strain
Trypanosoma cruzi sialoglycoproteins (Tc-mucins) are mucin-like molecules linked to a parasite membrane via a glycosylphosphatidylinositol anchor. We previously determined the structures of Tc-mucin O-glycan domains from several T. cruzi strains and observed significant differences among them. We now report the amino acid content and structure of Tc-mucin O-
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07