Trypsin Inhibition
Mostrando 1-12 de 309 artigos, teses e dissertações.
-
1. RP-HPLC and LC–MS–MS determination of a bioactive artefact from Ipomoea pes-caprae extract
Abstract Solvents play important and critical role in natural product chemistry and could generate artefacts during the extraction and purification of metabolites from a biological matrix. This study aimed to correlate the chromatographic profile with biological activity of Ipomoea pes-caprae (L.) R. Br., Convolvulaceae, extracts obtained with hydroethanolic
Rev. bras. farmacogn.. Publicado em: 09/12/2019
-
2. Protease inhibitory, insecticidal and deterrent effects of the trypsin-inhibitor benzamidine on the velvetbean caterpillar in soybean
Abstract The recognition of protease inhibitors with insecticidal activity is important as a basis for the development of mimetic peptides with potential use as biorational insecticides. We sprayed benzamidine on soybean plants and assessed whether this potent synthetic trypsin-inhibitor has protease inhibitory, insecticidal and deterrent effects on the velv
An. Acad. Bras. Ciênc.. Publicado em: 18/10/2018
-
3. Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes
ABSTRACT Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin
An. Acad. Bras. Ciênc.. Publicado em: 29/06/2017
-
4. Metanolic extract of Malpighia emarginata bagasse: phenolic compounds and inhibitory potential on digestive enzymes
ABSTRACT Adding value to fruit residues is of great interest, since they can be presented as a viable solution in search of new drugs for the treatment of obesity and related diseases, due to bioactive substances, especially phenolic compounds. Thus, the objective of this study was to prepare the methanol extract of acerola bagasse flour, in order to evaluat
Rev. bras. farmacogn.. Publicado em: 2016-04
-
5. First serine protease inhibitor isolated from Rhinella schneideri poison
Background Toad secretions are a source of molecules with potential biotechnological application on a wide spectrum of diseases. Toads from theRhinella family have two kinds of poisonous glands, namely granular and mucous glands. Rhinella schneideritoads produce granular secretions that comprise a great number of molecules, including serine proteases inhibit
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
-
6. Kazal-type serine proteinase inhibitors in the midgut of Phlebotomus papatasi
Sandflies (Diptera: Psychodidae) are important disease vectors of parasites of the genus Leishmania, as well as bacteria and viruses. Following studies of the midgut transcriptome of Phlebotomus papatasi, the principal vector of Leishmania major, two non-classical Kazal-type serine proteinase inhibitors were identified (PpKzl1 and PpKzl2). Analyses of expres
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
-
7. HydroPaCe: uma metodologia para análise de inibição cruzada em serino proteases através de centroides de regiões hidrofóbicas
Interfaces of protein-protein interactions contain important information about molecular recognition. This work aims at the discovery of conserved patterns in this region. We believe it is essential to understand how substrates and inhibitors are bound and for predicting molecular binding. When an inhibitor binds to enzymes with different structures, sequenc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/11/2011
-
8. CORRELAÇÃO DA ATIVIDADE DO PROTEASSOMA, EXPRESSÃO DE CD44 E ENZIMAS PROTEOLÍTICAS EM EXTRATOS INTESTINAIS DE CAMUNDONGOS TRATADOS COM 1,2 DIMETILHIDRAZINA E INIBIDORES BOWMAN-BIRK
The Bowman-Birk inhibitors (BBI) are protein molecules containing two distinct inhibitory domains for trypsin and chymotrypsin-like enzymes. The interest for this class of inhibitors is based on studies which demonstrated a protective effect promoted by BBI, particularly for chemically-induced cancers. In the present work, we evaluated the effects of BBI iso
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/06/2011
-
9. Purificação parcial e caracterização cinética da inibição de proteases intestinais tripsina-like de Anticarsia gemmatalis / Partial purification and kinetic characterization of inhibition of gut trypsin-like proteases from Anticarsia gemmatalis
A Anticarsia gemmatalis (Lepidoptera), conhecida como lagarta da soja, é considerada a principal praga desta cultura, causando enormes prejuízos devido ao ataque herbívoro. Por causa da importância das proteases digestivas na fisiologia das larvas, o estudo de inibidores de proteases como agentes de controle de pragas tem recebido atenção contínua. A
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2011
-
10. Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC., Asteraceae: evaluation of antinutrients and effect on glycosidases
In order to confirm the traditional use of Baccharis trimera (Less.) DC., Asteraceae, for the reduction of weight, plant extracts were evaluated on the activity of pancreatic lipase (PL), an enzyme responsible for hydrolysis of triacylglycerols in the diet for its subsequent absorption. The aqueous and infused extracts did not show inhibitory activity on the
Revista Brasileira de Farmacognosia. Publicado em: 01/04/2011
-
11. Alterações biológicas, bioquímicas e ultra-estruturais em Spodoptera frugiperda (J. E. Smith, 1797) (Lepidoptera: Noctuidae) provocadas por extratos vegetais e compostos fenólicos / Changes biological, biochemical and ultrastructural in Spodoptera frugiperda (JE Smith, 1797) (Lepidoptera: Noctuidae) caused by plant extracts and phenolic compounds
The fall armyworm Spodoptera frugiperda is a polyphagous insect that causes damage in several crops, methods to control are often inefficient and this justifies the search for new forms of management. Thus, this study was to evaluate the effect of plant extracts and phenolic compounds on biological, biochemical and ultrastructural characteristics of S. frugi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/02/2010
-
12. CaracterizaÃÃo BioquÃmica Parcial do LÃtex de Cryptostegia grandiflora R. Br. e AÃÃo Contra o Vetor da Dengue. / Biochemical characterization of latex of Cryptostegia grandiflora and larvicidal activity against Aedes aegypti
Cryptostegia grandiflora R. Br. is a shurb belonging to Apocynaceae family popularly known as âunha de bruxaâ. There are few studies available about the latex from this species and preliminary assays had shown its action against Dengue vector. Thus, this study aimed to characterize the biochemical properties of Cr. grandiflora latex and to evaluate the act
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/02/2010