Tryptophan Hydroxylase
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. Corrigendum
Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, r
Braz. J. Psychiatry. Publicado em: 2020-04
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2. Cannabidiol in Parkinson’s disease
Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, r
Braz. J. Psychiatry. Publicado em: 2020-04
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3. Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial
Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, r
Braz. J. Psychiatry. Publicado em: 2020-04
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4. Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial
Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, r
Braz. J. Psychiatry. Publicado em: 11/11/2019
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5. DistribuiÃÃo e anÃlise quantitativa de neurÃnios imunoreativos à enzima triptofano hidroxilase em nÃcleos de rafe de ratos desnutridos durante a vida perinatal / Distribution and quantitative analysis of neurons immunoreactive for the enzyme tryptophan hydroxylase in the raphe nuclei of animals malnourished during perinatal life
Nutritional disorders occurring during the development of the nervous system may program the fetal metabolism so long to allow the survival of individuals to changes in the nutritional environment. The perinatal protein malnutrition promotes neurochemical changes, including the levels of serotonin and limiting enzyme for its synthesis, tryptophan hydroxylase
Publicado em: 2009
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6. Noradrenergic synchronization and the role of insulin on the modulation of melatonin synthesis in cultured rat pineal gland. / A sincronização noradrenérgica e o papel da insulina na modulação da síntese da melatonina pela glândula pineal de ratos.
A glândula pineal de mamíferos sintetiza o hormônio melatonina exclusivamente durante o período noturno. A síntese é regulada primordialmente pela via retino-hipotalâmico-pineal e modulada por vários fatores, incluindo o sistema peptidérgico. Assim, o papel da insulina na regulação da síntese de melatonina foi estudado a partir da realização de
Publicado em: 2008
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7. Análise morfológica dos órgãos de stress de autopsias perinatais.
Introdução: O objetivo deste estudo foi o de avaliar através de técnicas de imunohistoquímica e morfometria a morfologia dos órgãos que apresentavam descrição na literatura de lesões morfológicas relacionadas ao stress perinatal: supra-renal (SR), timo (TI), fígado (FI) e placenta (PL), em 3 diferentes tipos de causa de morte perinatal: Hipóxia/
Publicado em: 2007
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8. Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin.
Tryptophan hydroxylase [tryptophan 5-monooxygenase, L-tryptophan,tetrahydropterin:oxygen oxidoreductase (5-hydroxylating), EC 1.14.16.4] is activated by phosphorylating conditions (ATP-Mg2+) in a calcium-dependent, cyclic AMP-independent manner. Addition to the phosphorylation reaction of certain antipsychotic drugs that bind to calmodulin, the heat-stable c
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9. Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.
A full-length cDNA for tryptophan hydroxylase was cloned from rabbit pineal body by screening an expression library with antibody against rat phenylalanine hydroxylase, which crossreacts with rabbit tryptophan hydroxylase. Clones producing immunoreactive material contain sequences homologous to, yet distinct from, phenylalanine hydroxylase. The rabbit cDNA h
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10. Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain.
Tryptophan hydroxylase [EC 1.14.16.4; L-tryptophan, tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating)], the enzyme catalyzing the rate-limiting step in the biosynthesis of serotonin, was purified 79-fold from the region of the raphe nucleus of rat midbrain by sequential column chromatography and disc-gel electrophoresis. In electrophoresis three ba
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11. High-level expression and deletion mutagenesis of human tryptophan hydroxylase.
Human tryptophan hydroxylase has been expressed as a soluble and active form in Escherichia coli by fusion with an affinity tag, maltose-binding protein. The fusion protein has been purified to near homogeneity by affinity chromatography on crosslinked amylose resin. The purified fusion protein has a specific activity of 86 nmol of 5-hydroxytryptophan per mi
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12. "7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases.
The ability of 2-amino-4-hydroxy-7-[dihydroxylpropyl-(L-erythro)-5,6,7,8-tetrahyd ropterin] ("7-tetrahydrobiopterin" or 7-BH4) to substitute for the natural cofactor tetrahydrobiopterin (BH4) has been studied in vitro in the reactions of the three mammalian aromatic amino acid hydroxylases. With rat liver phenylalanine hydroxylase, the apparent Km for 7-BH4