Tryptophan Oxidation
Mostrando 1-12 de 50 artigos, teses e dissertações.
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1. Evaluation of a Graphite-Polyurethane Composite Electrode Modified with Copper Nanoparticles as an Amperometric Flow Detector in a Wall-Jet System for the Determination of Cysteine
A graphite-polyurethane composite electrode (GPUE) was modified by electrodeposition of copper nanoparticles (CuNP) followed by electrochemical treatment in NaOH (GPUE-CuNP), in order to prepare an amperometric sensor for the determination of cysteine (Cys). Cyclic votammograms of Cys solutions at GPUE-CuNP allowed the description of a sequence of electroche
J. Braz. Chem. Soc.. Publicado em: 2020-02
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2. The long and successful journey of electrochemically active amino acids. From fundamental adsorption studies to potential surface engineering tools.
ABSTRACT Proteins have been the subject of electrochemical studies. It is possible to apply electrochemical techniques to obtain information about their structure due to the presence of five electroactive amino acids that can be oriented to the outside of the peptidic chain. These amino acids are L-Tryptophan (L-Trp), L-Tyrosine (L-Tyr), L-Histidine (L-His),
An. Acad. Bras. Ciênc.. Publicado em: 11/01/2018
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3. OXIMES AS INHIBITORS OF LOW DENSITY LIPOPROTEIN OXIDATION / OXIMAS COMO INIBIDORES DA OXIDAÇÃO DE LIPOPROTEÍNAS DE BAIXA DENSIDADE
The oxidation of low density lipoprotein is now an established hypothesis of atherogenesis and suggests that accumulation of oxidized low density lipoprotein (oxLDL) in the vessel wall is an early event in disease progression. OxLDL represents a variety of modification of both lipid and apolipoprotein B (apoB) components by peroxidation. This promotes athero
Publicado em: 2009
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4. Oxidação do triptofano pelo oxigênio molecular no estado singlete [O2 (1Δg)]: estudos mecanísticos envolvendo marcação isotópica, espectrometria de massa e quimiluminescência / Tryptophan oxidation by singlet molecular oxygen [(O2(1Δg): mechanistic studies using isotopic labelling, mass spectrometry analysis and chemiluminescence
As proteínas são consideradas importantes alvos para os oxidantes, devido à abundância em sistemas biológicos e às altas constantes de reações com estas espécies. Adicionalmente, têmse demonstrado que o triptofano (W) é um aminoácido extremamente susceptível a oxidação, inclusive pelo oxigênio singlete (1O2). A reação do W com o 1O2 tem des
Publicado em: 2008
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5. Tryptophan, melatonin and its oxidation produts: action on T lymphocytes / Triptofano, melatonina e seus produtos de oxidação: ações sobre os linfócitos T
Os linfócitos T sofrem rígida regulação homeostática desde seu desenvolvimento até sua maturação, expansão clonal e morte celular. Compostos endógenos ou exógenos que alterem as funções fisiológicas dos linfócitos T podem modular passos importantes da resposta imune. Triptofano tem um papel importante na manutenção da homeostasia dos linfóc
Publicado em: 2007
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6. Oxidação de proteínas por oxigênio singlete: mecanismos de dano, estratégias para detecção e implicações biológicas
Proteins are potential targets for singlet molecular oxygen (¹O2) oxidation. Damages occur only at tryptophan, tyrosine, histidine, methionine, and cysteine residues at physiological pH, generating oxidized compounds such as hydroperoxides. Therefore, it is important to understand the mechanisms by which ¹O2, hydroperoxides and other oxidized products can
Química Nova. Publicado em: 2006-06
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7. Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid
Hypochlorous acid (HOCl) released by activated leukocytes has been implicated in the tissue damage that characterizes chronic inflammatory diseases. In this investigation, 14 indole derivatives, including metabolites such as melatonin, tryptophan and indole-3-acetic acid, were screened for their ability to inhibit the generation of this endogenous oxidant by
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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8. Determination of crude protein and amino acids in soybean mealby Near Infrared Spectroscopy / Determinação de proteina bruta e aminoacidos em farelo de soja por espectroscopia no infravermelho proximo
In this work it was determined the amount of crude protein and amino acids in soybean meal by using near infrared spectroscopy and multivariate calibration base on partial least squares method (PLS). It was used 150 samples from different brazilian regions divided in several suppliers as Bunge, Caramuru, Cargill, Ceval and ADM that insure a good distribution
Publicado em: 2005
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9. Eficencia fotodinamica das protoporfirinas IX de magnesio e zinco
The photodynamic efficiency of protoporphyrin IX (PpIX) and its magnesium (MgPpIX) and zinc (ZnPpIX) derivatives were investigated by comparing the rate of tryptophan (Trp), bovine albumin (BSA) and erythrocytes photoxidation. The solutions of the biomolecules were irradiated with a mercury lamp, for a maximum period of 120 minutes and their photoxidations w
Publicado em: 2003
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10. Thyroid peroxidase activity is inhibited by amino acids
Normal in vitro thyroid peroxidase (TPO) iodide oxidation activity was completely inhibited by a hydrolyzed TPO preparation (0.15 mg/ml) or hydrolyzed bovine serum albumin (BSA, 0.2 mg/ml). A pancreatic hydrolysate of casein (trypticase peptone, 0.1 mg/ml) and some amino acids (cysteine, tryptophan and methionine, 50 µM each) also inhibited the TPO iodide o
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-03
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11. Ghost protein damage by peroxynitrite and its protection by melatonin
We have studied the effect of peroxynitrite (ONOO-) on the membrane cytoskeleton of red blood cells and its protection by melatonin. Analysis of the protein fraction of the preparation by SDS-PAGE revealed a dose-dependent (0-600 µM ONOO-) disappearance at pH 7.4 of the main proteins: spectrin, band 3, and actin, with the concomitant formation of high-molec
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-01
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12. ADAPTIVE ENZYMATIC PATTERNS IN THE BACTERIAL OXIDATION OF TRYPTOPHAN