Tspo
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new therapeutic interventions. Because translocator protein (TSPO) levels are reduced in Leishmania amazonen
Mem. Inst. Oswaldo Cruz. Publicado em: 05/02/2018
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2. Importância da via do mevalonato nas neoplasias do córtex adrenal / Importance of mevalonate pathway in adrenocortical tumors
Introdução: A 3-hidroxi-3-metilglutaril coenzima A redutase (HMGCR) é a enzima limitante da via do mevalonato. Esta via, que tem como produto final o colesterol, gera inúmeros subprodutos, como os isoprenóides, essenciais para modificação pós-traducional de várias proteínas envolvidas em proliferação e crescimento celular. Em tecidos esteroidogê
Publicado em: 2011
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3. Efeitos do diazepam sobre o crescimento do tumor ascítico de Ehrlich: envolvimento do Receptor Periférico para Benzodiazepínico (PBR) ou Proteína Translocadora (TSPO) / Diazepam effects on Ehrlich ascitic tumor growth: role of Peripheral Benzodiazepine Receptor (PBR) or Translocator Protein (TSPO)
Os benzodiazepínicos são amplamente utilizados devido às suas propriedades ansiolíticas e sedativas mediadas pelo complexo GABAA no Sistema Nervoso Central. Porém, posteriormente foi demonstrado que os mesmos também atuam no Receptor Periférico para Benzodiazepínico (PBR), conhecido atualmente como Proteína Translocadora (TSPO), expresso tanto em c�
Publicado em: 2009
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4. Estudo do sistema neuroimunoendócrino na caquexia neoplásica e da resposta ao tratamento com esteróides
The anorexia-cachexia syndrome (ACS), of multifactorial source and complex, is common in chronic diseases, like advanced cancer. Is associated with weight loss and decrease food intake, sometimes causing death. The objective of the present study was to evaluate the influence of neoplastic cachexia over the hypothalamus-pituitary-adrenal axis and immune syste
Publicado em: 2008
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5. TspO as a Modulator of the Repressor/Antirepressor (PpsR/AppA) Regulatory System in Rhodobacter sphaeroides 2.4.1
The TspO outer membrane protein of Rhodobacter sphaeroides has been shown to be involved in controlling the transcription of a number of genes which encode enzymes involved in photopigment biosynthesis and the puc operon. The display of regulated genes appears identical to those genes encompassing the PpsR/AppA repressor/antirepressor regulon, although the e
American Society for Microbiology.
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6. Translocator Protein 2 Is Involved in Cholesterol Redistribution during Erythropoiesis*
Translocator protein (TSPO) is an 18-kDa cholesterol- and drug-binding protein conserved from bacteria to humans. While surveying for Tspo-like genes, we identified its paralogous gene, Tspo2, encoding an evolutionarily conserved family of proteins that arose by gene duplications before the divergence of avians and mammals. Comparative analysis of Tspo1 and
American Society for Biochemistry and Molecular Biology.
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7. Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models
Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18-kDa drug- and cholesterol-binding protein localized to the outer mitochondrial membrane and implicated in a variety of cell and mitochondrial functions. To determine the role of TSPO in ischemia-reperfusion injury (IRI), we used both in vivo and in vitro porc
American Physiological Society.
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8. A mammalian mitochondrial drug receptor functions as a bacterial “oxygen” sensor
The rat mitochondrial outer membrane-localized benzodiazepine receptor (MBR) was expressed in wild-type and TspO− (tryptophan-rich sensory protein) strains of the facultative photoheterotroph, Rhodobacter sphaeroides 2.4.1, and was shown to retain its structure within the bacterial outer membrane as assayed by its binding properties with a variety of MBR l
The National Academy of Sciences of the USA.
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9. A Homologue of the Tryptophan-Rich Sensory Protein TspO and FixL Regulate a Novel Nutrient Deprivation-Induced Sinorhizobium meliloti Locus
A nutrient deprivation-induced locus in Sinorhizobium meliloti strain 1021 was identified by use of a Tn5-luxAB reporter gene transposon. The tagged locus is comprised of two open reading frames (ORFs) designated ndiA and ndiB for nutrient deprivation-induced genes A and B. Comparison of the deduced amino acid sequences of both ndiA and ndiB to the protein d
American Society for Microbiology.
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10. Genomic DNA Microarray Analysis: Identification of New Genes Regulated by Light Color in the Cyanobacterium Fremyella diplosiphon
Many cyanobacteria use complementary chromatic adaptation to efficiently utilize energy from both green and red regions of the light spectrum during photosynthesis. Although previous studies have shown that acclimation to changing light wavelengths involves many physiological responses, research to date has focused primarily on the expression and regulation
American Society for Microbiology.