Tubocurarine
Mostrando 1-12 de 158 artigos, teses e dissertações.
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1. Isolation, purification and pharmalogical and biochemical characterization of a new PLA2 (Bp12) from Bothrops pauloensis venom / Isolamento, purificação e caracterização bioquimica e farmacologica de uma nova fosfolipase A2 (Bp12) do veneno de Bothrops pauloensis
The myotoxic effects caused by bothropics venoms are unquestionable by their exuberant clinic manifestation and are extensively related in literature, since the neurotoxic effects have been described in vitro conditions, in nerve-muscle preparations, with little or neither clinic evidence. The aim of this study was to contribute for the knowledge about the p
Publicado em: 2008
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2. Pharmacological characterization of ASP49 PLA2 isolated from Bothrops pauloensis venom / Caracterização farmacologica de uma fosfolipase A2 ASP49 isolada do veneno de Bothrops pauloensis
Bothropic venom has several substances necessary to serpent survival, among them, one of the most widely studied are phospholipase A2 enzymes, that hydrolise sn-2 from membrane phospholipids, releasing lysophospholipids and fatty acids, which beyond playing a biological action in the lipid digestion process, also exhibit a wide variety of pharmacological eff
Publicado em: 2008
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3. Influencia dos anestesicos locais no bloqueio neuromuscular produzido por diferentes bloqueadores neuromusculares : estudo experimental / The influence of local anesthetics on neuromuscular blockade produced by differents neuromusculars blockades : experimental study
Local anesthetics commonly used in clinical practice can interact with neuromuscular blockers and potentiate their effects. Many authors studied this interaction, but the mechanism involved in the potentiation of neuromuscular blockers and the action of local anesthetics in the pre and postjunctional sites were not completely elucidated- In this study, in sp
Publicado em: 2006
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4. Preliminary studies with a neurotoxin obtained from Bungarus caeruleus venom
The neurotoxin purified from the venom of Bungarus caeruleus causes a neuromuscular blockade on acetylcholine-induced muscle twitch response in isolated frog rectus abdominis muscle preparation. Neuromuscular blockade produced by d-tubocurarine on acetylcholine-induced muscle twitch response in an isolated frog rectus abdominis muscle preparation was reverse
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2006
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5. Purinergic central pathways involved in the muscle blood flow regulation during alerting defense behaviours. / Vias centrais purinérgicas envolvidas na regulação do fluxo sangüíneo muscular durante os comportamentos de alerta e defesa
The electrical stimulation (ES) of the hypothalamus in the rat produces a well- defined pattern of cardiovascular adjustments including hypertension, tachycardia and skeletal muscle vasodilation. These hemodynamic responses can also be observed in natural conditions during fight and/or flight behaviors. However the neural pathways and possible neurotransmitt
Publicado em: 2006
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6. L- and DL-carnitine induce tetanic fade in rat neuromuscular preparation
Carnitine, a structurally choline-like metabolite, has been used to increase athletic performance, although its effects on neuromuscular transmission have not been investigated. It is present in skeletal muscle and its plasma levels are about 30 to 90 µM. Using rat phrenic nerve diaphragm preparations indirectly and directly stimulated with high rate pulses
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-09
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7. 4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP
The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP. Since NO, cGMP and 4-aminopyridine alone induce tetanic fade and increase amplitude of muscular contractions in isola
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-07
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8. Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)
Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses. In the present study, the pharmacological profile of trimethylsulfonium was characterized on muscarinic and nicotinic acetylcholine receptors. In rat jejunum the co
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-04
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9. Antagonism by hemoglobin of effects induced by L-arginine in neuromuscular preparations from rats
Nitric oxide (NO)-synthase is present in diaphragm, phrenic nerve and vascular smooth muscle. It has been shown that the NO precursor L-arginine (L-Arg) at the presynaptic level increases the amplitude of muscular contraction (AMC) and induces tetanic fade when the muscle is indirectly stimulated at low and high frequencies, respectively. However, the precur
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-04
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10. Estudo comparativo dos venenos de escorpiões tityus bahiensis e tityus serrulatus e serrulatus e de suas principais toxinas
T. bahiensis and T.serrulatus are the main scorpion species involved in envenomations in the Brazil, the latter being the more widely distributed. Clinically, envenomations by T. serrulatus is more serious than that by T. bahiensis. In this thesis, the lethal and neurotoxic activities of venoms from these two species were compared. Male Swiss withe mice (18-
Publicado em: 2000
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11. Sobre o emprego da 4-aminopiridina, 3.4-diaminopiridina e da neostigmina como antagonista de curare : estudo comparativo
The effects ot 4-aminopyridine (1; 5 e 25 ug/ml), 3.4-diaminopyridine (1; 5 and 25 ug/ml) as well as the association of the drugs with neostigmine, were investigated using the noncurarized rat s phrenic nerve-hemidiaphragm preparations and d-tubocurarine-blocked preparations. The preparations were treated by two different procedures; indirect estimulation by
Publicado em: 1981
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12. Presynaptic effects of d-tubocurarine on neurotransmitter release at the neuromuscular junction of the frog.
1. Presynaptic effects of d-tubocurarine on neurotransmitter release were examined at the frog neuromuscular junction, using intracellular and extracellular recording techniques. 2. d-Tubocurarine in concentrations of 10(-7)-10(-6) M decreased the quantal content (m) measured by the coefficient of variation and failure methods. 3. d-Tubocurarine produced a s