Tumor Resistance
Mostrando 1-12 de 711 artigos, teses e dissertações.
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1. An easy and practical prognostic parameter: tumor–stroma ratio in Luminal, Her2, and triple-negative breast cancers
SUMMARY OBJECTIVE: The stroma surrounding the tumor cells is important in tumor progression and treatment resistance, besides the properties of tumor cells. Studies on the tumor stroma characteristics will contribute to the knowledge for new treatment approaches. METHODS: A total of 363 breast cancer patients were evaluated for the tumor–stroma ratio. Th
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Efficacy of cabergoline add-on therapy in patients with acromegaly resistance to somatostatin analogs treatment and the review of literature
ABSTRACT Objective: It is reported that adding cabergoline to somatostatin analog (SSA) normalizes IGF-1 levels approximately in one-third of patients with acromegaly. We investigated the effect of combination therapy and potential predictors of response in patients with acromegaly who do not respond to SSA therapy alone. Subjects and methods: Fifty acrome
Archives of Endocrinology and Metabolism. Publicado em: 2022
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3. Editorial Comment: Effects of testicular dysgenesis syndrome components on testicular germ cell tumor prognosis and oncological outcomes
ABSTRACT Pesticide environmental risks and increased weed resistance have encouraged studies for alternatives to herbicides. Among these are weed thermal control methods by controlled heat application machines. Thus, this study aimed to test a prototype of heat-applicator machine as a function of changes in gas pressure, travel speed, and tire traffic effect
Int. braz j urol.. Publicado em: 2020-10
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4. Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors
ABSTRACT Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. The aim of this study was to evaluate the risk of recurre
Int. braz j urol.. Publicado em: 2020-06
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5. Growth hormone in the tumor microenvironment
ABSTRACT Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cance
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
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6. Is Surgical Treatment an Option for Locally Advanced Cervical Cancer in the Presence of Central Residual Tumor after Chemoradiotherapy?
Abstract Objective To evaluate the outcomes of surgical treatment in patients with chemoradiotherapy (CRT)-resistant and locally advanced cervical cancer (LACC). Methods Patients with LACC who underwent surgery due to resistance to CRT between 2005 and 2015 were reviewed retrospectively. Disease-free survival (DFS) and overall survival (OS) related facto
Rev. Bras. Ginecol. Obstet.. Publicado em: 2020-01
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7. The Use of Antidepressant Drugs in Climacteric Syndrome
Abstract Objective To evaluate the outcomes of surgical treatment in patients with chemoradiotherapy (CRT)-resistant and locally advanced cervical cancer (LACC). Methods Patients with LACC who underwent surgery due to resistance to CRT between 2005 and 2015 were reviewed retrospectively. Disease-free survival (DFS) and overall survival (OS) related facto
Rev. Bras. Ginecol. Obstet.. Publicado em: 2020-01
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8. DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance
Abstract Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five years or more. Several pieces of evidence have suggested that the DNA damage signaling and repair activities are directly correl
Genet. Mol. Biol.. Publicado em: 13/12/2019
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9. Short-term high-fat diet affects macrophages inflammatory response, early signs of a long-term problem
Obesity is a chronic inflammatory disease that affects millions of people worldwide. Most studies observe the effects of a high-fat diet (HFD) in 10-12 weeks. This work investigated the effects induced by a HFD administered for 6 weeks on the nutritional status of mice and some aspects of the inflammatory response in mouse peritoneal macrophages. Male Swiss
Braz. J. Pharm. Sci.. Publicado em: 28/10/2019
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10. Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
RESUMO Objetivo Avaliar os efeitos de três tipos de treinamentos de resistência na adiposidade, na inflamação e na ação da insulina em camundongos Swiss obesos por dieta hiperlipídica. Métodos Camundongos Swiss machos magros e obesos foram selecionados e posteriormente separados em oito grupos com oito animais em cada: dieta padrão + não treinado
Einstein (São Paulo). Publicado em: 23/09/2019
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11. The unusual paradox of cancer-associated inflammation: an update
RESUMO A resposta inflamatória representa um componente fundamental do microambiente tumoral, sendo responsável por mediar a rede de comunicação biológica e o fluxo de sinalização molecular, que caracterizam o tecido neoplásico. Desse modo, influenciadas pelo processo inflamatório, células neoplásicas e não neoplásicas (estromais e circulantes j
J. Bras. Patol. Med. Lab.. Publicado em: 01/08/2019
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12. Resistance Exercise Modulates Oxidative Stress Parameters and TNF-α Content in the Heart of Mice with Diet-Induced Obesity
Resumo Fundamento: A obesidade pode ser caracterizada por uma inflamação crônica de baixo grau e está associada à produção excessiva de espécies reativas de oxigênio, fatores que contribuem para doenças coronarianas e outras cardiomiopatias. Objetivo: Verificar os efeitos do treinamento resistido sobre os parâmetros de estresse oxidativo e par
Arq. Bras. Cardiol.. Publicado em: 25/04/2019