Ubiquitin Proteasome
Mostrando 1-12 de 465 artigos, teses e dissertações.
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1. Genome-wide identification, characterisation and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata
BACKGROUND Biomphalaria glabrata is the major species used for the study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational regulation in order to maintain cellular protein homeostasis and is related to several mechanisms, i
Mem. Inst. Oswaldo Cruz. Publicado em: 03/06/2019
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2. Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents
Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Herein, we used cell c
Braz J Med Biol Res. Publicado em: 19/10/2017
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3. Plant arginyltransferases (ATEs)
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One imp
Genet. Mol. Biol.. Publicado em: 13/02/2017
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4. Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni
Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an important role in Ub-depen
Mem. Inst. Oswaldo Cruz. Publicado em: 04/11/2013
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5. Caracterização de putativo receptor serpentino e estudos sobre a implicação do sistema de ubiquitina/proteossomo na modulação do ciclo celular de Plasmodium falciparum. / Caracterization of serpentine receptor putative and studies about the implication of ubiquitin/proteasome system in Plasmodium falciparum cell cycle.
É proposto que vias de sinalização controlem a sobrevivência e adaptação do Plasmodium, nos diferentes hospedeiros. No presente trabalho buscamos por diferentes abordagens estudar a via de sinalização de melatonina em P. falciparum. Para isso, avaliamos os níveis de RNA mensageiro de genes do sistema-ubiquitina proteossomo (UPS) bem como o perfil de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/05/2012
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6. Modulação do metabolismo muscular em camundongos exercitados e suplementados com leucina / Modulation of muscle metabolism by exercise and leucine supplementation in mice
We investigated the effects of chronic physical training, associated or not with leucine supplementation, on protein and glucose metabolism in soleus muscle of Swiss mice. Half of the mice (T) performed a 12 weeks protocol of swimming exercise, 1h/day, 5 days/week, bearing no overload, and the other half remained sedentary (C). Additionally, half of the C an
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/02/2012
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7. Development of an in vitro model of expanded ataxin-3 cytotoxic effects and evaluation of different therapeutic strategies to control of these effects / Desenvolvimento de um modelo in vitro dos efeitos citotóxicos da ataxina-3 expandida e avaliação de diferentes estratégias terapêuticas para o controle desses efeitos
Spinocerebellar ataxia-3 (SCA3), also known as Machado-Joseph disease (MJD), belongs to a group of neurodegenerative disorders caused by expansion of a polyglutamine stretch, called polyglutamine diseases. MJD is the most frequent inherited autosomal dominant ataxia in many countries. Clinical manifestations are varied, including abnormal motor coordination
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/02/2010
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8. Análise bioquímica inicial do proteassoma em populações do Trypanosoma cruzi com diferentes fenótipos de resistência ao benzonidazol
Differences in susceptibility to benznidazole (Bz) and nifurtimox (NFX) among populations of Trypanosoma cruzi may explain, at least in part, the differences in efficacy of treatment of Chagas disease. The proteasome has an important role in the degradation of normal proteins, damaged, mutated, or denatured, including the degradation of regulatory proteins o
Publicado em: 2010
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9. Efeito do treinamento físico aeróbico sobre a atrofia muscular associada à insuficiência cardíaca: contribuição do sistema ubiquitina proteassoma dependente de ATP / Effects of aerobic exercise training on skeletal muscle atrophy associated with heart failure: role of ubiquitin-proteasome pathway
A atrofia está associada ao aumento da degradação protéica em doenças sistêmicas, sendo o sistema proteolítico ubiquitina proteassoma (SUP) uma das principais vias envolvidas. Contudo, pouco é conhecido sobre a contribuição do SUP à atrofia desencadeada pela insuficiência cardíaca (IC). Sabendo dos benefícios do treinamento físico aeróbico (T
Publicado em: 2010
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10. Associação entre o proteassoma e o inibidor de protease BTCI : caracterização fisico-química e efeitos moleculares em células de câncer de mama (MCF-7)
Dietas ricas em leguminosas têm sido associadas à baixa incidência de câncer em populações humanas, sendo essas plantas, ricas em inibidores de proteases. O BTCI (black-eyed pea trypsin/chymotrypsin inhibitor) é um inibidor de protease da família Bowman-Birk, isolado de sementes da leguminosa Vigna unguiculata (feijão-de-corda), que inibe a tripsina
Publicado em: 2010
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11. Caracterização da participação do sistema de ubiquitinação e degradação proteassômica no bloqueio do ciclo celular mediado pela proteína Vpr do HIV-1
HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis. In the present study, we investigate the role of the ubiquitin/proteasome system (UPS) in the above activity of Vpr. We report that the general function of the UPS is required
Publicado em: 2008
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12. Effect of the triiodothyronine (T3) and the thyroid receptor beta selective agonist GC-24 upon rat skeletal muscle trophism: expression of proteasome-dependent genes. / Efeito da triiodotironina (T3) e do agonista TRb seletivo GC-24 sobre o trofismo muscular esquelético de ratos: aspectos envolvendo a proteólise dependente de proteassoma.
Triiodothyronine (T3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms a/pha (TRa) and beta (TRI3). Abnormalities in skeletal muscle function have been associated with increased leveis of T3, which is a major sarcopenia (Ioss of sarcomeres). Although the phenomenon of sarcopenia induced by T3 has
Publicado em: 2008