Ubiquitination
Mostrando 1-12 de 544 artigos, teses e dissertações.
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1. Retraction notice for: “Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination” [Braz J Med Biol Res (2019) 52(9): e8525]
Braz J Med Biol Res. Publicado em: 05/12/2019
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2. [RETRACTED ARTICLE] Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death of chondrocytes; therefore, finding an effective and non
Braz J Med Biol Res. Publicado em: 12/08/2019
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3. Genome-wide identification, characterisation and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata
BACKGROUND Biomphalaria glabrata is the major species used for the study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational regulation in order to maintain cellular protein homeostasis and is related to several mechanisms, i
Mem. Inst. Oswaldo Cruz. Publicado em: 03/06/2019
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4. Auxinic herbicides, mechanisms of action, and weed resistance: A look into recent plant science advances
Auxin governs dynamic cellular processes involved at several stages of plant growth and development. In this review, we discuss the mechanisms employed by auxin in light of recent scientific advances, with a focus on synthetic auxins as herbicides and synthetic auxin resistance mechanisms. Two auxin receptors were reported. The plasma membrane receptor ABP1
Sci. agric. (Piracicaba, Braz.). Publicado em: 2015-08
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5. Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni
Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an important role in Ub-depen
Mem. Inst. Oswaldo Cruz. Publicado em: 04/11/2013
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6. Modificação pós-traducional pendente de SUMO em Schistosoma mansoni: padrão de expressão diferencial durante a transição de cercária a esquistossômulo
Attachment of SUMO to target proteins occur through by similar mechanism to ubiquitination, with sequential action of three enzymes: E1 activating (Aos1-Uba2), E2 conjugation (Ubc9) and E3 ligases (PIAS, Polycomb2 and RanBP2). SUMO is synthesized as inactive precursors that require processing by specific proteases (SENPs). SUMO attachment is a reversible and
Publicado em: 2010
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7. O gene UBE2A (Ubiquitin conjugating enzyme 2 A) e a deficiência mental: triagem de mutações e estudos funcionais / UBE2A (Ubiquitin conjugating enzyme 2 A) gene and mental retardation: search for mutations and functional studies
Em trabalho anterior, identificamos a mutação c.382C8594;T no gene UBE2A, localizado em Xq24 e codificador de enzima conjugadora de ubiquitina, como causa de nova síndrome de deficiência mental (DM) de herança ligada ao cromossomo X. Foi a primeira descrição de mutação nesse gene e a primeira associação de mutação em gene que codifica conjugase
Publicado em: 2010
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8. Expression of E-cadherin, Snail and Hakai in epithelial cells isolated from the primary tumor and from peritumoral tissue of invasive ductal breast carcinomas
Epithelial intercellular cohesion, mainly mediated by E-cadherin (CDH1) expression and function, may be deregulated during cancer cell invasion of adjacent tissues and lymphatic and vascular channels. CDH1 expression is down-modulated in invasive lobular breast carcinomas but its regulation in invasive ductal carcinomas (IDC) is less clear. CDH1 expression i
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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9. Study of Arkadia expression, ubiquitination E-3 protein, in thyroid tumors and its relation to the TGF-beta signaling pathway. / Estudo da expressão de Arkadia, proteína E3 de ubiquitinação, em tumores de tiróide e sua relação com a via de sinalização de TGF-Beta.
Arkadia participa do processo de amplificação da sinalização de TGF-b mediada por Smads, via degradação do I-Smad. O objetivo desse estudo foi caracterizar e investigar a influência de Arkadia em linhagens celulares de cânceres de tiróide. A expressão gênica de Arkadia em linhagens celulares de carcinomas papílifero (NPA), folicular (WRO) e anapl
Publicado em: 2009
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10. Effect of the triiodothyronine (T3) and the thyroid receptor beta selective agonist GC-24 upon rat skeletal muscle trophism: expression of proteasome-dependent genes. / Efeito da triiodotironina (T3) e do agonista TRb seletivo GC-24 sobre o trofismo muscular esquelético de ratos: aspectos envolvendo a proteólise dependente de proteassoma.
Triiodothyronine (T3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms a/pha (TRa) and beta (TRI3). Abnormalities in skeletal muscle function have been associated with increased leveis of T3, which is a major sarcopenia (Ioss of sarcomeres). Although the phenomenon of sarcopenia induced by T3 has
Publicado em: 2008
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11. Caracterização da participação do sistema de ubiquitinação e degradação proteassômica no bloqueio do ciclo celular mediado pela proteína Vpr do HIV-1
HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis. In the present study, we investigate the role of the ubiquitin/proteasome system (UPS) in the above activity of Vpr. We report that the general function of the UPS is required
Publicado em: 2008
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12. Sistemas neuromodulatórios: implicações fisiopatológicas / Neuromodulatory systems: patophysiologic implications
Adenosine has been shown to modulate cardiovascular control at the levels of the nucleus tractus solitarii (NTS). This study shows the distribution and density of adenosine A1 receptor within the nucleus tractus solitarii (NTS) of Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats from birth to adulthood (1,15,30 and 90 day-old). [3H]DPCPX was used
Publicado em: 2008