Uroguanylin
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Estudo dos efeitos da alta ingestÃo de cloreto de sÃdio por via oral sobre o metabolismo diÃrio e funÃÃo renal de ratos. / Study of effects on the daily metabolism and the renal function of rats under high oral ingestion of sodium chloride.
Guanylin (GN), uroguanylin (UGN), and the bacterial heat-stable enterotoxin (ST) peptides comprise a new family of cyclic guanosine 3â-5â monophosphate (cGMP)-regulating agonist. Ingestion of a salt meal induces secretion of GN and UGN into the intestinal lumen, where they inhibit Na+ absorption and induces Cl-, HCO3- , and water secretion. Simultaneously,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/01/2009
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2. Efeito da uroguanilina sobre o transporte de hidrogênio em túbulos renais de rins de rato e em linhagens de células proximais e distrais / Effect of Uroguanylin on hydrogen transport in rat renal tubules and in proximal and distal cells lines
Uroguanilina (UGN) é um peptídeo normalmente sintetizado no intestino que modula o balanço de sódio através de ações renais. Investigamos os efeitos e os mecanismos de sinalização envolvidos na ação da UGN sobre a secreção de H+, em túbulos renais de ratos e em células LLC-PK1 (proximais) e MDCK-C11 (distais). Nos estudos in vivo foi utilizada
Publicado em: 2009
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3. AÃÃes farmacolÃgicas da ser-thr-lys-guanilina em sistema de perfusÃo de rim isolado de rato / Pharmacological actions of ser-thr-lys-guanilina in isolated perfused rat kidney
Guanylin and uroguanylin are members of a family of peptides that stimulates cGMP production in several organic tissues, as intestine, kidney, airway, linfonodes, testis, brain and adrenal medulla (Field et a.l., 1978; Forte et al., 1988, 1989; Hamra et al., 1993; Schulz et al., 1992). Their 15 amino acid structures have been identified from rat intestine an
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2005
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4. Eletrophysiological evaluation of guanylin and urogunylin in rat brain / Avaliação eletrofisiológica da ação da guanilina e de uroguanilina em cérebro de ratos
Os peptídeos termo-estáveis guanilina e uroguanilina foram inicialmente isolados e identificados do intestino de rato e de urina de opossum: suas propriedades são atribuídas ao controle do transporte de sal e água no rim e intestino, mediado pelo GMPc. O presente estudo propõe-se a avaliar a atividade neurofisiológica dos peptídeos do tipo guanilina,
Publicado em: 2003
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5. Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity
Guanylin and uroguanylin are intestinal peptides that stimulate chloride secretion by activating a common set of receptor–guanylate cyclase signaling molecules located on the mucosal surface of enterocytes. High mucosal acidity, similar to the pH occurring within the fluid microclimate domain at the mucosal surface of the intestine, markedly enhances the c
The National Academy of Sciences of the USA.
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6. Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load
Guanylin and uroguanylin, peptides synthesized in the intestine and kidney, have been postulated to have both paracrine and endocrine functions, forming a potential enteric-renal link to coordinate salt ingestion with natriuresis. To explore the in vivo role of uroguanylin in the regulation of sodium excretion, we created gene-targeted mice in which uroguany
American Society for Clinical Investigation.
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7. A novel role for uroguanylin in the regulation of sodium balance
Uroguanylin is a peptide hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. A new study demonstrates that mice deficient in uroguanylin have blunted urinary sodium excretion responses to oral sodium loads in addition to elevated blood pressure (see related article beginning on page 1244). A physiological role for uroguanylin
American Society for Clinical Investigation.
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8. Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.
The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate the human intestinal T84 cell guanylate cyclase have been purified from urine and intestinal mucosa of opossums (Didelphis virginiana). The highly acidic peptid
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9. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
The effects of Escherichia coli heat-stable enterotoxin (ST) and uroguanylin were examined on the proliferation of T84 and Caco2 human colon carcinoma cells that express guanylyl cyclase C (GC-C) and SW480 human colon carcinoma cells that do not express this receptor. ST or uroguanylin inhibited proliferation of T84 and Caco2 cells, but not SW480 cells, in a
The National Academy of Sciences.
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10. Differential display of intestinal mRNAs regulated by dietary zinc.
Regulation of gene expression by zinc is well established, especially through the metal response elements of the metallothionein genes; however, most other aspects of the functions of zinc in gene expression remain unknown. We have looked for intestinal mRNAs that are regulated by dietary zinc status. Using the reverse transcriptase-PCR method of mRNA differ
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11. Modulation of intestinal gene expression by dietary zinc status: Effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency
Mammalian nutritional status affects the homeostatic balance of multiple physiological processes and their associated gene expression. Although DNA array analysis can monitor large numbers of genes, there are no reports of expression profiling of a micronutrient deficiency in an intact animal system. In this report, we have tested the feasibility of using cD
The National Academy of Sciences.