Vaccine Vectors
Mostrando 1-12 de 228 artigos, teses e dissertações.
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1. SOLUÇÕES A BASE DE ÁLCOOL PARA HIGIENIZAÇÃO DAS MÃOS E SUPERFÍCIES NA PREVENÇÃO DA COVID-19: COMPÊNDIO INFORMATIVO SOB O PONTO DE VISTA DA QUÍMICA ENVOLVIDA
The recent coronavirus pandemic has already victimized hundreds of thousands of people around the world, and until this moment does not exist any medicine for healing or vaccine to avoid the contamination. Therefore, the actions of social isolation associated with the use of masks and surface and hand sanitation are the most effective actions to avoid the vi
Quím. Nova. Publicado em: 2020-05
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2. Immunohistochemistry contribution in the diagnosis of splenic marginal zone lymphoma
The recent coronavirus pandemic has already victimized hundreds of thousands of people around the world, and until this moment does not exist any medicine for healing or vaccine to avoid the contamination. Therefore, the actions of social isolation associated with the use of masks and surface and hand sanitation are the most effective actions to avoid the vi
Rev. Assoc. Med. Bras.. Publicado em: 2020-05
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3. Live bacterial vaccine vectors: An overview
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enab
Braz. J. Microbiol.. Publicado em: 2014-12
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4. Clonagem molecular do gene ipaC de Shigella sp e estudo da expressão por Lactococcus lactis / Molecular cloning and expression analysis in Lactococcus lactis of ipaC gene from Shigella sp
Shigellosis is a severe intestinal infection caused by Gram-negative bacteria which belongs to the genus Shigella. It is a pathology with high incidence and it is known that 99% of cases occur in underdevelopment countries. Among these cases, 69% of them affect children under 5 years old. The high incidence of Shigella in underdevelopment countries, is mainl
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/05/2012
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5. Recombinant vaccines and the development of new vaccine strategies
Vaccines were initially developed on an empirical basis, relying mostly on attenuation or inactivation of pathogens. Advances in immunology, molecular biology, biochemistry, genomics, and proteomics have added new perspectives to the vaccinology field. The use of recombinant proteins allows the targeting of immune responses focused against few protective ant
Braz J Med Biol Res. Publicado em: 2012-12
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6. Production of L1 protein from different types of HPV in Pichia pastoris using an integrative vector
Human papillomavirus (HPV) infection is the most common sexually transmitted disease in the world and is related to the etiology of cervical cancer. The most common high-risk HPV types are 16 and 18; however, the second most prevalent type in the Midwestern region of Brazil is HPV-33. New vaccine strategies against HPV have shown that virus-like particles (V
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12
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7. Synergism/complementarity of recombinant adenoviral vectors and other vaccination platforms during induction of protective immunity against malaria
The lack of immunogenicity of most malaria antigens and the complex immune responses required for achieving protective immunity against this infectious disease have traditionally hampered the development of an efficient human malaria vaccine. The current boom in development of recombinant viral vectors and their use in prime-boost protocols that result in en
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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8. Modulação da apresentação antigênica por células dendríticas derivadas de monócitos utilizando diferentes produtos virais do HIV: potencial de utilização em vacina terapêutica. / Modulation of monocyte-derived dendritic cell antigen presentation using different HIV antigenic: potential use in therapeutic vaccine.
Despite more than 20 years of effort, the design of an effective HIV-1 vaccine remains an enormous challenge. In this scenario, new immunological approaches must be considered. Monocytes from HIV-serodiscordant couples and non HIV exposed controls were differentiated in vitro into dendritic cells (MoDC), pulsed with different virus antigens and cultured with
Publicado em: 2010
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9. Development of a therapeutic vaccine against HPV16 / Desenvolvimento de vacina terapêutica contra HPV16
Cervical cancer is the second most common cancer among women worldwide. Most cases (83%) occur in developing countries, where they are found in relatively advanced stages and, consequently, the median survival is about 49% after five years. Therefore, an effective vaccine against HPV infections can lead to control of cancer of the cervix. Although preventabl
Publicado em: 2010
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10. CARACTERIZAÇÃO DE GENES DO VÍRUS DO ECTIMA CONTAGIOSO ENVOLVIDOS NA REGULAÇÃO DA VIA DE SINALIZAÇÃO DO NF-κB / CHARACTERIZATION OF ORF VIRUS-ENCODED GENES INVOLVED IN THE REGULATION OF THE NF-κB SIGNALING PATHWAY
Orf virus (ORFV), the type member of the genus Parapoxvirus of the family Poxviridae, is the etiologic agent of orf or contagious ecthyma, a contagious and ubiquitous disease of sheep and goats. ORFV genome consists of a double stranded DNA molecule with approximately 138 Kb, and contains 131 putative genes. Among those, 15 are novel genes, unique to parapox
Publicado em: 2010
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11. Is an HIV vaccine possible?
The road to the discovery of a vaccine for HIV has been arduous and will continue to be difficult over the ensuing twenty years. Most vaccines are developed by inducing neutralizing antibodies against the target pathogen or by using attenuated strains of the particular pathogen to engender a variety of protective immune responses. Unfortunately, simple metho
Brazilian Journal of Infectious Diseases. Publicado em: 2009-08
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12. Clonagem, expressão e purificação de proteínas candidatas vacinais de Leptospira interrogans sorovar Copenhageni. Avaliação de atividades imunogênicas e características funcionais. / Cloning, expression and purification of proteins, vaccine candidates from Leptospira interrogans sorovar Copenhageni. Evaluation of immunogenic and functional characteristics.
Leptospirosis is a zoonosis worldwide distributed, caused by bacteria from the genus Leptospira. The development of an efficient vaccine of sub-unities would be of major interest for public health. We proposed to investigate 4 antigens from Leptospira interrogans srv Copenhageni, genes LIC12659, LIC12660, LIC12631 and LIC10868, which were amplified and clone
Publicado em: 2009