Vacuous Chewing Movements
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Animal models for predicting the efficacy and side effects of antipsychotic drugs
The use of antipsychotic drugs represents an important approach for the treatment of schizophrenia. However, their efficacy is limited to certain symptoms of this disorder, and they induce serious side effects. As a result, there is a strong demand for the development of new drugs, which depends on reliable animal models for pharmacological characterization.
Rev. Bras. Psiquiatr.. Publicado em: 2013
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2. An examination of synaptic proteins following chronic haloperidol in a rat model of tardive dyskinesia
Tardive dyskinesia (TD) is a late-onset side effect mainly affecting the orofacial region of patients treated chronically with classic antipsychotic drugs such as haloperidol (HAL). The causes of TD remain unknown. We hypothesized that faulty synaptic re-organization might be related to TD-like syndromes and used the vacuous chewing movements (VCM) model in
Psychology & Neuroscience. Publicado em: 2010-12
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3. INGESTÃO DA TINTURA DE VALERIANA OFFICINALIS PROTEGE DA DISCINESIA OROFACIAL INDUZIDA POR RESERPINA EM RATOS / INTAKE OF THE VALERIANA OFFICINALIS TINCTURE PROTECTS AGAINST OROFACIAL DYSKINESIA INDUCED BY RESERPINE IN RATS
Considerando as hipóteses do papel da neurotransmissão gabaérgica e do estresse oxidativo no desenvolvimento de movimentos orais associados a neuropatologias importantes, o presente estudo investigou a possível habilidade da tintura de V. officinalis na prevenção dos movimentos de mascar no vazio (MMV) induzidos por reserpina em ratos. Os animais foram
Publicado em: 2009
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4. INFLUÊNCIA DO ÔMEGA 3 SOBRE SINTOMAS EXTRAPIRAMIDAIS, DEFICIÊNCIA COGNITIVA E PARÂMETROS DE ESTRESSE OXIDATIVO EM ANIMAIS TRATADOS COM NEUROLÉPTICOS
Haloperidol and fluphenazine are typical neuroleptics widely used in the treatment of mental illness, whose chronic use is associated with adverse effects that affect the motor function and memory, among others. The motor disturbances can be moderate, and include parkinsonism, akathisia, dystonia, but also a more severe syndrome, known as tardive dyskinesia
Publicado em: 2009
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5. ROLE OF DOPAMINE UPTAKE AND THEIR METABOLITES IN THE OROFACIAL DYSKINESIA INDUCED BY NEUROLEPTICS IN RATS / PAPEL DA RECAPTAÇÃO E DE METABÓLITOS DA DOPAMINA NA DISCINESIA OROFACIAL INDUZIDA POR NEUROLÉPTICOS EM RATOS
Fluphenazine-induced orofacial dyskinesia (OD) is a putative animal model of tardive dyskinesia (TD) whose pathophysiology has been related to an increase in dopamine hypersensitivity and oxidative stress. Data from literature have shown that patients with TD present a decrease in dopamine transporter (DAT) expression. In a previously study, we have demonstr
Publicado em: 2008
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6. INFLUENCE OF PHYSICAL EXERCISE ON BEHAVIORAL PARAMETERS AND OXIDATIVE STRESS IN AN ANIMAL MODEL OF TARDIVE DYSKINESIA / IFLUÊNCIA DO EXERCÍCIO FÍSICO SOBRE PARÂMETROS DE COMPORTAMENTO E ESTRESSE OXIDATIVO EM MODELO ANIMAL DE DISCINESIA TARDIA
Regular practice of physical activity promotes beneficial effects to the body. However, excessive duration and intensity of exercise may surpass individual tolerance to exercise, generating oxidative stress (OS). Studies have shown these effects in various organs, such as the heart and muscles, but little is known about their action and mechanisms in the bra
Publicado em: 2008