Venoms From Animals
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. Functional and biological insights of rCollinein-1, a recombinant serine protease from Crotalus durissus collilineatus
ABSTRACT Background: The prevalent class of snake venom serine proteases (SVSP) in Viperidae venoms is the thrombin-like enzymes, which, similarly to human thrombin, convert fibrinogen into insoluble fibrin monomers. However, thrombin-like serine proteases differ from thrombin by being unable to activate factor XIII, thus leading to the formation of loose c
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 08/04/2019
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2. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorioallantoic membrane model
Abstract Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion channels including those present in the ocular system. To study potential toxicity and safety of intravitreal injection in rabbits of
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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3. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand
Abstract Background: Envenoming by kraits (genus Bungarus) is a medically significant issue in South Asia and Southeast Asia. Malayan krait (Bungarus candidus) venom is known to contain highly potent neurotoxins. In recent years, there have been reports on the non-neurotoxic activities of krait venom that include myotoxicity and nephrotoxicity. However, res
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 07/05/2018
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4. Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom
Abstract Background The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snakebites, but it may cause numerous clinical side effects and have other disadvantages involved in their production such as the
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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5. Multiple uses of fibrin sealant for nervous system treatment following injury and disease
Abstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn furthe
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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6. Antiviral activity of animal venom peptides and related compounds
Abstract Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agent
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/02/2017
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7. Low-intensity laser therapy improves tetanic contractions in mouse anterior tibialis muscle injected with Bothrops jararaca snake venom
Abstract Introduction Envenomation by Bothrops snakes can produce local pain, edema, hemorrhage and myonecrosis. However, standard antivenom therapy is generally ineffective in neutralizing these effects so that alternative methods of treatment have been investigated. In experimental animals, low-level laser therapy (LLLT) attenuates the local effects of Bo
Res. Biomed. Eng.. Publicado em: 2016-06
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8. Antiproliferative activity of marine stingray Dasyatis sephenvenom on human cervical carcinoma cell line
AbstractBackgroundVenoms comprise mixtures of numerous bioactive compounds that have a wide range of pharmacologic actions. Toxins from venomous animals have attracted the attention of researchers because of their affinity for primary sites responsible for lethality and their efficacy at extremely low concentrations. The venoms of marine stingrays have not b
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 10/11/2015
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9. Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva
Arachnida is the largest class among the arthropods, constituting over 60,000 described species (spiders, mites, ticks, scorpions, palpigrades, pseudoscorpions, solpugids and harvestmen). Many accidents are caused by arachnids, especially spiders and scorpions, while some diseases can be transmitted by mites and ticks. These animals are widely dispersed in u
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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10. A bradykinin-potentiating peptide (BPP-10c) from Bothrops jararaca induces changes in seminiferous tubules
Background The testis-specific isoform of angiotensin-converting enzyme (tACE) is exclusively expressed in germ cells during spermatogenesis. Although the exact role of tACE in male fertility is unknown, it clearly plays a critical function in spermatogenesis. The dipeptidase domain of tACE is identical to the C-terminal catalytic domain of somatic ACE (sAC
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/11/2013
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11. Avaliação da atividade neuroprotetora da Parawixina 11 isolada da peçonha da aranha Parawixia bistriata (Araneae, Araneidae), em ratos Wistar submetidos a um modelo de glaucoma agudo / Neuroprotective activity analysis of Parawixin 11, isolated from Parawixia bistriata (Araneae, Araneidae) spider venom, in Wistar rats submitted to an model of acute glaucoma
Glaucoma is defined as a typical optic neuropathy characterized by ganglion cells loss and consequent optic nerve damage, resulting in a gradual reduction of the visual field and eventual blindness. In regard to compounds present in spider venoms, they represent an interesting source of bioactive molecules and the study about the possible neuroprotective eff
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2012
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12. Development of a sensitive enzyme immunoassay (ELISA) for specific identification of Lachesis acrochorda venom
The snake genus Lachesis provokes 2 to 3% of snakebites in Colombia every year. Two Lachesis species, L. acrochorda and L. muta, share habitats with snakes from another genus, namely Bothrops asper and B. atrox. Lachesis venom causes systemic and local effects such as swelling, hemorrhaging, myonecrosis, hemostatic disorders and nephrotoxic symptoms similar
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012