Venoms Production
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. The WHO strategy for prevention and control of snakebite envenoming: a sub-Saharan Africa plan
Abstract Snakebite is a critical public health issue in tropical countries, particularly in Africa, where 20% of snakebites globally occur. In 2017, the WHO added snakebite envenoming to the category A of neglected tropical diseases. In 2019, thanks to broad institutional and international NGO support, including strong mobilization of African experts and gov
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/12/2019
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2. Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine
Abstract Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrif
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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3. Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom
Abstract Background The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snakebites, but it may cause numerous clinical side effects and have other disadvantages involved in their production such as the
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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4. Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis
Abstract Background The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the venom may hamper the production of efficient elapid antivenoms. Therefore, the aim of the present study was to produce fully active elapid neurotoxic immunogens for elapid antivenom produc
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 13/10/2016
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5. Hepatotoxicity and oxidative stress induced byNaja haje crude venom
Background Snake venoms are synthesized and stored in venom glands. Most venoms are complex mixtures of several proteins, peptides, enzymes, toxins and non-protein components. In the present study, we investigated the oxidative stress and apoptosis in rat liver cells provoked by Naja haje crude injection (LD50) after four hours.Methods Wistar rats were rando
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/10/2014
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6. Molecular cloning of a hyaluronidase from Bothrops pauloensis venom gland
Background Hyaluronate is one of the major components of extracellular matrix from vertebrates whose breakdown is catalyzed by the enzyme hyaluronidase. These enzymes are widely described in snake venoms, in which they facilitate the spreading of the main toxins in the victim’s body during the envenoming. Snake venoms also present some variants (hyaluron
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 05/08/2014
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7. Efeito de uma fosfolipase A2 básica isolada da peçonha de Bothropoides pauloensis (Bothrops pauloensis) sobre formas promastigota de Leishmania (Leishmania) amazonensis
CHAPTER 2: Leishmaniasis is a group of diseases caused by protozoa of Leishmania genus. The currently available treatment for this disease presents high toxicity and cost, parasite resistance, and difficulties of healing. In this sense, the development of new strategies for treatment of leishmaniasis is indispensable and snake venoms appear as an important n
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011
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8. Análise do transcriptoma da glândula produtora de veneno de Loxosceles intermedia (aranhamarrom): perfil de expressão e identificação de novas toxinas. / Effects of metalloproteinas from Brotrops leucurus venon and brown spiders venoms on endothelial cell and components of extracellular matrix.
Loxosceles genus spiders are responsible for accidents all over the world and have clinical importance in the South of Brazil. The venom of these spiders is made up of several toxins, including proteins, which are responsible for the clinical pattern called loxoscelism. To describe the transcriptional profile of the L. intermedia venom gland, we generated a
Publicado em: 2010
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9. Análise proteômica parcial da peçonha do escorpião colombiano Centruroides margaritatus (Gervais, 1841)
Scorpion venoms are a complex mixture of peptides that exert their action via ion-channel modulation in biological membranes. The central objective of this project was to perform the proteomic characterization of the venom from the Colombian scorpion Centruroides margaritatus. This species is capable of producing moderate accidents and serious complications
Publicado em: 2008
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10. Efeito da peçonha de Bothrops moojeni sobre formas promastigotas de Leishmania spp
In order to develop alternative tools to subdue infectious diseases, several substances have been tested toward treatment of parasitoses, such as Leishmaniasis. For this purpose, snake venoms have been used as future drugs that disrupt the viability of protozoan. In this report, we evaluated the effect of Bothrops moojeni venom and its fractions on viability
Publicado em: 2008
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11. Estudos da inflamação e dor articulares em ratos e dos mecanismos da produção de TNF-a por macrófagos isolados, induzidos pela BaP1, uma metaloproteínase isolada do veneno da serpente Bothrops asper. / Studies on both rat articular inflammation and pain, and mechanisms involved in production of TNF-a by isolated macrophages induced by BaP1, a metalloproteinase isolated from Bothrops asper snake venom.
Metalloproteinases are major enzymes in snake venoms showing high grade of homology with mammal matrix metalloproteinases, present in high levels in inflamed joints. In this study we examined the ability of BaP1, to induce: i) inflammation and hypernociception in rat articular joints and participation of TNF-a and PGE2 in these effects, a
Publicado em: 2008
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12. Analise histologica do aparato venenifero e caracterização farmaco-bioquimica da peçonha de Vitalius dubius (Araneae, Theraphosidae) / Histological analysis of the venom apparatus and biochemical and pharmacological characterization of venom from Vitalius dubius (Araneae, Theraphosidae)
Vitalius dubius is a medium-sized, non-aggressive tarantula found in southeastern Brazil. In this work, we examined the histological organization of the venom apparatus of V. dubius and investigated some biochemical and pharmacological properties of this spider´s venom. The venom apparatus consisted of two chelicerae fitted with large fangs for prey immobil
Publicado em: 2008