Vesicular Acetylcholine Transporter Protein
Mostrando 1-7 de 7 artigos, teses e dissertações.
-
1. Evaluation of lung function and histopathology in an experimental model of chronic allergic pulmonary inflammation: effects of reduced cholinergic function in genetically modified mice / Avaliação da função e da histopatologia pulmonar em modelo experimental de inflamação pulmonar alérgica crônica: efeitos da redução da função colinérgica em camundongos geneticamente modificados
INTRODUÇÃO: A Asma Brônquica é caracterizada por obstrução ao fluxo aéreo, reversível ou não, e processo inflamatório pulmonar, caracterizado principalmente por eosinofilia. A persistência da inflamação pode induzir processo de reparo pulmonar associado à redução progressiva da função pulmonar. A recente descrição do sistema colinérgico
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/06/2012
-
2. Avaliação neuroquímica do sistema colinérgico de camundongos com o gene do transportador vesicular de acetilcolina (VAChT) modificado geneticamente
The vesicular acetylcholine transporter (VACht) is responsible for acetylcholine (Ach) storage in synaptic vesicles, an important step for cholinergic transmission. Our goal was to study the role of VAChT in cholinergic tonus maintenance through the generation of mice presenting alterations in VAChT gene by homologous recombination.. One of used strategies w
Publicado em: 2008
-
3. Sinais de tráfego envolvidos no envolvidos no endereçamento do transportador vesicular de acetilcolina (VAChT)
The vesicular acetylcholine transporter (VAChT) is the protein responsible for packaging cytoplasmic acetylcholine (ACh) into the synaptic vesicle of cholinergic neurons. The cytosolic C-terminal region of VAChT is important in intracellular trafficking events and targeting to secretory organelles. In this study, we evaluate the existence of trafficking sign
Publicado em: 2006
-
4. Funções motoras em camundongos deficientes do transportador vesicular de acetilcolina (VAChT)
Acetylcholine (ACh)mediated neurotransmission has a crucial role in the control of movement. Release of ACh depends on its storage in synaptic vesicles, a step controlled by the activity of the VAChT. We developed a genetically altered strain of mice with reduced expression of this transporter. Heterozygous (VAChT KDHET) and homozygous (VAChT KDHOM) knockdow
Publicado em: 2006
-
5. Molecular cloning of a putative vesicular transporter for acetylcholine.
Classical neurotransmitters such as acetylcholine (ACh) require transport into synaptic vesicles for regulated exocytotic release. The Caenorhabditis elegans gene unc-17 encodes a protein with homology to mammalian transporters that concentrate monoamine neurotransmitters into synaptic vesicles. Mutations in unc-17 protect against organophosphorus toxicity,
-
6. Nonvesicular release of acetylcholine is required for axon targeting in the Drosophila visual system
We report evidence for a developmental role of acetylcholine in axon pathfinding in the Drosophila visual system. Acetylcholine was detected on photoreceptor axons during their navigation to target sites in the brain, a time well before the formation of functional synapses. The pattern of photoreceptor axon projections was severely disrupted when acetylcholi
National Academy of Sciences.
-
7. Protein Kinase A Regulates Cholinergic Gene Expression in PC12 Cells: REST4 Silences the Silencing Activity of Neuron-Restrictive Silencer Factor/REST
The role of protein kinase A in regulating transcription of the cholinergic gene locus, which contains both the vesicular acetylcholine transporter gene and the choline acetyltransferase gene, was investigated in PC12 cells and a protein kinase A-deficient PC12 mutant, A126.1B2, in which transcription of the gene is reduced. The site of action of protein kin
American Society for Microbiology.