Vhl Syndrome
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Multiple renal tumorectomy in a Von Hipple Lindau patient. Combined retro/transperitoneal approach with intracorporeal hypotermia
ABSTRACT Objective & Introduction: To show the feasibility of a combined transperitoneal (TP) and retroperitoneal (RP) laparoscopic approach in a Von Hipple-Lindau (VHL) patient with multiple kidney tumors. VHL is an autosomal dominant inherited syndrome characterized by a high incidence of benign and malignant tumors and cysts in many organs. Renal cell ca
Int. braz j urol.. Publicado em: 20/12/2019
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2. Fatores facilitadores, principais dificuldades e estratégias empregadas no aleitamento materno de bebês com síndrome de Down: uma revisão sistemática
RESUMO Objetivo Investigar, na literatura, as principais dificuldades encontradas no aleitamento materno de bebês com síndrome de Down, os fatores facilitadores e as estratégias utilizadas para melhorar a amamentação desses bebês. Métodos Foi realizada uma revisão sistemática nas bases de dados PubMed, SciELO e BVS. Os termos utilizados foram sín
Audiol., Commun. Res.. Publicado em: 14/11/2019
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3. National scientific production on Burnout Syndrome in ICU nurses and physicians: a bibliometric study
RESUMO OBJETIVO: Analisar a produção científica sobre a Síndrome de Burnout em médicos e enfermeiros de UTI no Brasil. MÉTODO: Estudo bibliométrico, documental, com abordagem quantitativa. Foram selecionados artigos publicados no Brasil sobre a Síndrome de Burnout nas UTIs, na BVS e Portal Capes, entre 2000 e 2018. Foi elaborado um mapa conceitual
Rev. Assoc. Med. Bras.. Publicado em: 03/06/2019
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4. Avaliação das alterações do gene VHL nos carcinomas renais de células claras associados à síndrome de von Hippel-Lindau
A Síndrome de von Hippel-Lindau é uma doença hereditária multissistêmica, causada por mutações germinativas no gene VHL que predispõe o portador a manifestações benignas e malignas em diversos órgãos. Entre esses eventos, o carcinoma de células claras renais (CRC) é o de pior prognóstico, com uma penetração média de 25% e sendo a principal
Publicado em: 2010
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5. Estudo da expressão dos genes regulatórios de hipóxia durante a inflamação pulmonar produzida pela isquemia e reperfusão intestinal em camundongos AIRmax e AIRmin / Study of hypoxia regulatory genes expression during lung inflammation produced by intestinal ischemia-reperfusion in AIRmax and AIRmin mice
Oxygen homeostasis is essential for survival and physiologic development of organisms. Lack of O2 in tissues is a common underlying factor in morbidity and mortality for numerous serious medical conditions such as the Acute Respiratory Distress Syndrome (ARDS). For homeostasis recovery the myeloid cells exert their functions in specialized areas of hypoxia.
Publicado em: 2009
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6. Preimplantation genetic diagnosis of Von Hippel-Lindau disease cancer syndrome by combined mutation and segregation analysis
Von Hippel-Lindau (VHL) disease is an autosomal dominant cancer syndrome, associated with the development of tumors and cysts in multiple organ systems, whose expression and age of onset are highly variable. The VHL disease tumor suppressor gene (VHL) maps to 3p25-p26 and mutations ranging from a single base change to large deletions have been detected in pa
Genetics and Molecular Biology. Publicado em: 2007-03
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7. Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the familial cancer syndrome, VHL disease, characterized by a predisposition to renal cell carcinoma and other tumor types. Loss of VHL gene function also is found in a majority of sporadic renal carcinomas. A preponderance of the tumor-disposing inherited missense mutations detected in
The National Academy of Sciences.
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8. VHL Induces Renal Cell Differentiation and Growth Arrest through Integration of Cell-Cell and Cell-Extracellular Matrix Signaling
Mutations in the von Hippel-Lindau (VHL) gene are involved in the family cancer syndrome for which it is named and the development of sporadic renal cell cancer (RCC). Reintroduction of VHL into RCC cells lacking functional VHL [VHL(−)] can suppress their growth in nude mice, but not under standard tissue culture conditions. To examine the hypothesis that
American Society for Microbiology.
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9. The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
The inactivation of the von Hippel–Lindau (VHL) tumor suppressor gene predisposes affected individuals to the human VHL cancer syndrome and is associated with sporadic renal cell carcinomas (RCC) and brain hemangioblastomas. VHL-negative 786–0 RCC cells are tumorigenic in nude mice which is suppressed by the reintroduction of VHL. Remarkably, this occurs
The National Academy of Sciences.
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10. Transcription-Dependent Nuclear-Cytoplasmic Trafficking Is Required for the Function of the von Hippel-Lindau Tumor Suppressor Protein
Mutation of the von Hippel-Lindau tumor suppressor gene (vhl) causes the von Hippel-Lindau cancer syndrome as well as sporadic renal clear cell carcinoma. To pursue our study of the intracellular localization of VHL protein in relation to its function, we fused VHL to the green fluorescent protein (GFP) to produce the VHL-GFP fusion protein. Like VHL, VHL-GF
American Society for Microbiology.
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11. Diverse Effects of Mutations in Exon II of the von Hippel-Lindau (VHL) Tumor Suppressor Gene on the Interaction of pVHL with the Cytosolic Chaperonin and pVHL-Dependent Ubiquitin Ligase Activity
We examined the biogenesis of the von Hippel-Lindau (VHL) tumor suppressor protein (pVHL) in vitro and in vivo. pVHL formed a complex with the cytosolic chaperonin containing TCP-1 (CCT or TRiC) en route to assembly with elongin B/C and the subsequent formation of the VCB-Cul2 ubiquitin ligase. Blocking the interaction of pVHL with elongin B/C resulted in ac
American Society for Microbiology.
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12. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS hemangioblastomas. The VHL protein (pVHL) has been shown to form a stable complex with elongin B and elongin C, two factors that stabilize and activate the transcription elon
The National Academy of Sciences of the USA.