Voltage Dependent Calcium Channels
Mostrando 1-12 de 423 artigos, teses e dissertações.
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1. Anticonvulsant mechanism of saponins fraction from adventitious roots of Ficus religiosa: possible modulation of GABAergic, calcium and sodium channel functions
ABSTRACT In our previous studies, quantified saponins-rich fraction from adventitious root extract of Ficus religiosa L., Moraceae, showed anticonvulsant effect in acute, as well as chronic mice models of epilepsy. The present study was designed to reveal putative anticonvulsant mechanism of quantified saponins-rich fraction using target specific animal mode
Rev. bras. farmacogn.. Publicado em: 2016-10
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2. A metanandamida, um agonista canabinóide, protege a linhagem de neuroblastoma neuro2A da morte celular induzida por peróxido de hidrogênio. / The methanandamide, a cannabinoid agonist, protect the lineage of neuro 2A cell death induced by hydrogen peroxide.
Neurodegenerative diseases are progressive disorder affecting specific neuronal populations in the central nervous system, leading to neuronal death. Several factors contribute to the development of neurodegenerative diseases, including increased free radical formation and / or oxidative stress. The cannabinoid system has been suggested as an important syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/07/2012
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3. Renal- and calcium-dependent vascular effects of Polybia paulista wasp venom
In the present study, the effects of Polybia paulista venom (PPV) on renal and vascular tissues were investigated. Isolated kidneys perfused with PPV (1 and 3 μg/mL) had increased perfusion pressure, renal vascular resistance, urinary flow, and glomerular filtration rate; and reduced sodium tubular transport. Histological evaluation demonstrated deposits of
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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4. Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
INTRODUCTION: Gynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied. OBJECTIVES: To investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats. METHODS: Anaesthetized rats wer
Clinics. Publicado em: 2011
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5. Expressão gênica e protéica do canal de cálcio do tipo L e seu envolvimento com o mecanismo de secreção de insulina em ilhotas de langerhans de ratos submetidos à restrição protéica e suplementados com leucina / Gene and protein expression of L type calcium channel and your involvement in the mechanism of insulin secretion in islets of Langerhans of rats submitted to protein restriction and supplementation with leucine
Voltage-dependent calcium channels (CaV) are plasma membrane proteins that lead calcium, and are activated by depolarization of the same by promoting the influx of this ion, which serves as an intracellular second messenger, turning electrical signals into chemical. This process controls several intracellular events such as exocytosis, endocytosis, muscle co
Publicado em: 2010
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6. Avaliação dos efeitos induzidos pelo 2-Nitrato-1, 3-Dibutoxipropano (NDBP) sobre o sistema cardiovascular de ratos normotensos - abordagens en vivo e in vitro
Organic nitrates are nitric oxide (NO) donors used in the treatment of cardiovascular diseases mimicking the role of endogenous NO. This study evaluated organic nitrates newly synthesized from glycerin, which cardiovascular actions had not yet been investigated. Therefore, the cardiovascular effects produced by organic nitrates derived from glycerin: 2-nitra
Publicado em: 2010
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7. Efeito neuroprotetor do anestésico propofol em fatias de hipocampo de ratos submetidos à isquemia cerebral in vitro
There are several studies that propofol, an intravenous anesthetic, reduces neuronal injury due to brain ischemia. However, the results of such neuroprotection in ischemic models have been conflicting, both in vitro and in vivo studies. In addition, the mechanisms involved in propofol neuroprotection have not been clarified. The aim of the present study was
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2009
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8. Investigação do efeito vasorelaxante e caracterização eletrofisiológica dos alcalóides curina e reticulina
It was been demonstrated that curine and reticuline, induced a vasodilator effect in the rat small mesenteric arteries through inhibition of voltage-gated Ca2+ channels (VGCC). These compounds, curine and reticuline were isolated from the root barks of Chondrondendron platyphyllum and Ocotea duckei Vattimo, respectively, therefore the aim of this work was to
Publicado em: 2009
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9. Estudo do efeito Antinociceptivo do Eugenol / Study of the antinociceptive effect of Eugenol
Eugenol is a fenolic derivative being chemically designated as 4-alil-2-metóxifenol, well-known usually as carnation essence, because this present in great quantity in the essential oil of carnation of India (Eugenia aromatic), but this present also in the cinnamon, sassafras and myrrh. Eugenol bears several pharmacological effects among them can highlight:
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/01/2008
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10. Caracterização da atividade antinociceptiva de peptídeos homólogos ao C-terminal da proteína S100A9 murina. Ação sobre neurônios sensoriais via canais de cálcio dependentes de voltagem do tipo N / Characterization of the antinociceptive effect of peptides homologous to the C-terminus of murine S100A9 protein. Effects on sensory neurons, via type-N voltage-dependent calcium channels
O peptídeo idêntico ao C-terminal da proteína S100A9 murina (pS100A9mH92-G110) inibe a hiperalgesia inflamatória induzida pela carragenina. Em adição, este peptídeo inibe a hiperalgesia inflamatória induzida por tripsina, uma serino protease capaz de ativar receptores ativados por protease do tipo 2 (PAR2). O objetivo inicial deste trabalho foi carac
Publicado em: 2006
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11. Calcium antagonism and the vasorelaxation of the rat aorta induced by rotundifolone
The vasorelaxing activity of rotundifolone (ROT), a major constituent (63.5%) of the essential oil of Mentha x villosa, was tested in male Wistar rats (300-350 g). In isolated rat aortic rings, increasing ROT concentrations (0.3, 1, 10, 100, 300, and 500 µg/ml) inhibited the contractile effects of 1 µM phenylephrine and of 80 or 30 mM KCl (IC50 values, rep
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-12
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12. Efeito de bloqueadores de canais de íons cálcio sobre espermatozóides e oócitos de hamsters fecundados in vivo e in vitro / Effects of calcium ion channel blockers on hamster spermatozoa and oocytes in in vivo and in vitro fertilization
Fertilization process is closely related with calcium ion. There are reports about voltage-dependent calcium ion channel blockers of anti-hypertension therapeutic use causing male infertility, but there are few reports about such effects on the oocyte. The main goal of this experiment was to check the influence of verapamil, nifedipine and diltiazem (L-type
Publicado em: 2004