White Adipose Tissues
Mostrando 1-12 de 33 artigos, teses e dissertações.
-
1. Renin-angiotensin system blockers regulate the metabolism of isolated fat cells in vitro
Due to the presence of the renin-angiotensin system (RAS) in tissues and its specific influence on white adipose tissue, fat cells are possible targets of pharmacological RAS blockers commonly used as anti-hypertensive drugs. In the present study, we investigated the effects of different RAS blockers on fat cell metabolism, more specifically on lipolysis, li
Braz J Med Biol Res. Publicado em: 28/07/2016
-
2. Lipolysis and lipases in white adipose tissue – An update
Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies
Arch. Endocrinol. Metab.. Publicado em: 2015-08
-
3. Combretum lanceolatum flowers extract shows antidiabetic activity through activation of AMPK by quercetin
The present study evaluated the antidiabetic activity of the Combretum lanceolatum Pohl ex Eichler, Combretaceae, flowers extract (ClEtOH) in diabetic rats. Streptozotocin-diabetic rats were divided into four groups: diabetic control, diabetic treated with 500 mg/kg of metformin and diabetic treated with 250 or 500 mg/kg of ClEtOH for 21 days. The treatment
Rev. bras. farmacogn.. Publicado em: 04/12/2012
-
4. The adipocyte size contributes to the functional heterogeneity of white adipose tissue / O volume celular do adipócito contribui para a heterogeneidade funcional do tecido adiposo branco
The adipose tissue was considered to be a little active metabolic tissue, however, the most recent advances show that it plays an important function in the control of the energy homostasis. Based on this concept, this work aimed to characterize the morphology and metabolism of isolated adipocytes of three different depots, like: subcutaneous, periepididymal,
Publicado em: 2010
-
5. Influência de um novo produto fermentado de soja sobre o metabolismo lipídico tecidual em ratos submetidos a uma dieta enriquecida com colesterol.
In relation to many types of diets, soybean has been researched as a possible cohelping resource in the treatment of diverse pathologies. Therefore, the objective of this current work was to investigate the manifestation of a new soybean fermented product with added Enteroccocus Faecium and Lactobaccilus Jugurti on the lipid metabolism of male Wistar rats, a
Publicado em: 2005
-
6. GLUT4 protein expression in obese and lean 12-month-old rats: insights from different types of data analysis
GLUT4 protein expression in white adipose tissue (WAT) and skeletal muscle (SM) was investigated in 2-month-old, 12-month-old spontaneously obese or 12-month-old calorie-restricted lean Wistar rats, by considering different parameters of analysis, such as tissue and body weight, and total protein yield of the tissue. In WAT, a ~70% decrease was observed in p
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-10
-
7. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma (PPARgamma), which is expressed primarily in adipose tissues. To elucidate the mechanism by which troglitazone relieves insulin resistance in vivo, we studied its effects on the white adipose tissues of an obese animal model (obese Zucker
-
8. Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in adipocyte differentiation, glucose metabolism, and other physiological processes. To further explore the role of PPARγ in adipose tissues, we used a Cre/loxP strategy to generate adipose-specific PPARγ knockout mice. These animals exhibited marked abnormalities in the formation
National Academy of Sciences.
-
9. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist.
The mitochondrial uncoupling protein (UCP) is usually expressed only in brown adipose tissue (BAT) and a key molecule for metabolic thermogenesis. The effects of a highly selective beta 3-adrenergic agonist, CL316,243 (CL), on UCP expression in skeletal muscle and adipose tissues were examined in mice. Daily injection of CL (0.1 mg/kg, sc) to obese yellow KK
-
10. Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling*
Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance. Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and insulin sensitivity despite triacylglycerol accumulation in multiple tissues. To d
American Society for Biochemistry and Molecular Biology.
-
11. Tissue distribution of beta 3-adrenergic receptor mRNA in man.
Expression of mRNA for beta 1-, beta 2-, and beta 3-adrenergic receptors (beta 1-, beta 2-, and beta 3-AR) was investigated in human tissues. beta 1- and beta 2-AR mRNA distribution correlated with that of the cognate receptors established by pharmacological studies. beta 3-AR transcripts were abundant in infant perirenal brown adipose tissue, characterized
-
12. Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations
In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning and performs metabolic regulatory functions. It is the most flexible tissue in the body, because it is remodeled in size and shape by modifications in adipocyte cell size and/or number, depending on developmental status and energy fluxes. Although numerous reviews have f
American Society for Investigative Pathology.