Wnt Proteins
Mostrando 1-12 de 108 artigos, teses e dissertações.
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1. Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and chronic renal disease: a cross-sectional study
ABSTRACT BACKGROUND: Diabetic nephropathy is a common complication of chronic kidney disease (CKD). Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade
Sao Paulo Med. J.. Publicado em: 2020-03
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2. Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression
Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed to clarify the functions of emodin in hypoxia-induced i
Braz J Med Biol Res. Publicado em: 25/02/2019
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3. MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts
Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression leve
Braz J Med Biol Res. Publicado em: 18/10/2018
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4. Effect of Wnt/β-catenin and NF-κB signaling pathways on mucus secretion with hypertonicity in 16HBE cells
This study aimed at identifying the molecular mechanisms and effects of hypertonicity on mucin5AC (MUC5AC) expression in airway epithelial cells for which immortalized human bronchial epithelial (16HBE) cells were cultured in 600 mOsm/L hypertonic medium for different times in vitro. Proteins of MUC5AC and β-catenin, Cyclin D1, NF-κB p65 were detected by e
Braz. arch. biol. technol.. Publicado em: 2013-08
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5. CTNNB1, AXIN1 and APC expression analysis of different medulloblastoma variants
OBJECTIVES: We investigated four components of the Wnt signaling pathway in medulloblastomas. Medulloblastoma is the most common type of malignant pediatric brain tumor, and the Wnt signaling pathway has been shown to be activated in this type of tumor. METHODS: Sixty-one medulloblastoma cases were analyzed for β-catenin gene (CTNNB1) mutations, β-catenin
Clinics. Publicado em: 2013
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6. Análise da expressão imunoistoquímica de proteínas associadas a via de sinalização Wnt/ß-catenina em ameloblastomas sólidos e tumores odontogênicos císticos calcificantes / Analysis of the immunohistochemical expression of proteins associated with Wnt/ß-catenin signaling in ameloblastomas and calcifying cystic odontogenic tumors
Ameloblastoma (SMA) is one of the most common odontogenic tumors (OT), and although benign, it may have aggressive clinical behavior, be locally destructive and invasive, while calcifying cystic odontogenic tumor (CCOT) is a benign cystic OT that presents microscopic similarities with AME, but, in general, it has a less aggressive clinical behavior. Wnt/ß--
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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7. Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults
Wnt proteins are involved in tissue development and their signaling pathways play an important role during embryogenesis. Wnt signaling can promote cell survival, which is beneficial for neurons, but could also lead to tumor development in different tissues. The present study investigated the effects of a Wnt protein on the susceptibility of a neural tumor c
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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8. Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system
Refractory and relapsed leukemia is a major problem during cancer therapy, which is due to the aberrant activation of Wnt/β-catenin signaling pathway. Activation of this pathway is promoted by wingless (Wnt) proteins and induces co-activator β-catenin binding to lymphoid enhancer factor (LEF)/T-cell factor protein (TCF). To provide a convenient system for
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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9. GTPases Rho e o potencial regenerativo da retina de mamíferos / Rho GTPases and the regenerative potential of the mammalian retina
Ciliary Body (CB) is a potential source of stem cells in the adult retina, but its activation is still unknown. Rho GTPases play a role in actin-based cytoskeleton reorganization, regulate signaling pathways and gene transcription, cell survival and cell proliferation. In this study we investigated the expression of Rho GTPases in CB cells and their role on
Publicado em: 2010
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10. Análise da expressão dos genes PROP1 e CTNNB1 em craniofaringiomas adamantinomatosos com e sem mutação somática no CTNNB1 / Analysis of PROP1 and CTNNB1 expression genes in adamantinomatous craniopharyngiomas with and without CTNNB1 somatic mutation
Os craniofaringiomas são os tumores mais frequentes da região hipotálamohipofisária na faixa etária pediátrica. Apesar de serem histologicamente benignos, sua tendência infiltrativa e seu comportamento agressivo resultam em significante morbimortalidade. Histologicamente podem ser divididos em dois subtipos: adamantinomatosos e papilíferos. A patogê
Publicado em: 2010
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11. Avaliação da expressão imunoistoquímica das proteínas β-Catenina e Wnt-5a em carcinoma escamocelular de boca.
Oral squamous cell carcinoma (OSCC) is the most common histological form of head and neck cancer. Because of the highly aggressive evolution of some tumors, more knowledge is needed about its biological behavior, which may be achieved using immunohistochemical markers. Wnt-5a, of the Wnt family, is frequently upregulated in certain human cancers, and it can
Publicado em: 2008
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12. Envolvimento da Beta-catenina na via Wnt em meduloblastomas: estudo molecular e imunohistoquímico / Involvement of b-catenin gene in WNT pathway in medulloblastoma: molecular and immunohistochemical analysis
Meduloblastoma é um tumor embrionário maligno e invasivo do cerebelo, com manifestação preferencial em crianças, sendo predominantemente de diferenciação neuronal e tendência natural a metastatização por via liquórica. O gene da b-catenina (CTNNB1) está localizado no cromossomo 3p22-p21-3, sendo seu produto uma proteína citoplasmática de 92 kDa
Publicado em: 2007